Evidence map›Paper›PMID 40491851›Full record

ArticleInternational journal of nanomedicine2025

Multi-Response Au-Nanohybrid Composite Triggered NIR-Light for Effective Anti-Tumor Therapy in Animal Model.

Ling-Zhijie Kong, Dong Zhou, Guoyan Mo, Mingyue Shu, Wenyan Yu, Hao Cheng, Kaichun Li

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ling-Zhijie Kong *Department of Oncology, Shanghai Fourth People's Hospital, Tongji University School of Medicine, Shanghai, 200434, People's Republic of China.
Dong Zhou *The State Key Laboratory of Bioreactor Engineering and Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, People's Republic of China.
Guoyan Mo *China Key Laboratory of TCM Resource and Prescription, Ministry of Education, Hubei University of Chinese Medicine, Wuhan, 430065, People's Republic of China.
Mingyue ShuChina Key Laboratory of TCM Resource and Prescription, Ministry of Education, Hubei University of Chinese Medicine, Wuhan, 430065, People's Republic of China.
Wenyan YuDepartment of Oncology, Shanghai Fourth People's Hospital, Tongji University School of Medicine, Shanghai, 200434, People's Republic of China.
Hao ChengDepartment of Oncology, Shanghai Fourth People's Hospital, Tongji University School of Medicine, Shanghai, 200434, People's Republic of China.
Kaichun LiDepartment of Oncology, Shanghai Fourth People's Hospital, Tongji University School of Medicine, Shanghai, 200434, People's Republic of China.ORCID 0000-0001-6442-4388

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The therapeutic efficacy of nanomedicine in oncology is predicated on its capacity to enhance drug uptake by cells and control drug release. While targeted nanomedicines are highly regarded for their potential, they are not spared from issues of colloidal instability and uncontrolled drug release. Methods: The hybrid system (Au@SiO Results: Under NIR irradiation, the nanoparticles exhibited excellent photothermal stability and sustained temperature elevation. In vitro studies demonstrated that the nanoparticles possessed good biocompatibility (cell viability exceeding 90%) and colloidal stability (7 days). The loading efficiency of DOX was enhanced to 65.9%, with sustained release characteristics. Furthermore, Au@SiO Conclusion: This nanohybrid system represents a promising strategy for improving the efficacy of chemotherapy and reducing toxicity in cancer treatment. It enhances drug enrichment and release in tumor tissues while minimizing the impact on normal tissues.

Indexed as

DoxorubicinGoldAnimalsAntineoplastic AgentsCell Line, TumorCell SurvivalDrug CarriersDrug Delivery SystemsDrug LiberationFemaleHumansHyaluronic AcidInfrared RaysMiceMice, Inbred BALB CNanotubesAntineoplastic AgentsDoxorubicinDrug CarriersGoldHyaluronic AcidSilicon Dioxidegold nanorodshigh colloidal stabilitypH/ROS-responsivetumor microenvironmenttumor-targeted therapy

Identifiers

PMID40491851
PMCPMC12147814

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.