ReviewClinical kidney journal2025
Renal denervation is effective in reducing blood pressure in patients with CKD.
Review in Clinical kidney journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Salt and chronic kidney disease.Nature reviews. Nephrology · 2026Review
- Management of hypertension in chronic kidney disease.Clinical medicine (London, England) · 2026Review
- Reframing renal denervation: from blood pressure reduction to autonomic disease modification-a state-of-the-art review.Clinical hypertension · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertension is a major cause and the predominant accelerator of progressive loss of renal function in patients with chronic kidney disease (CKD). Despite advances in pharmacological intervention in recent years, a significant proportion of patients with CKD have uncontrolled, often treatment-resistant hypertension, necessitating alternative therapeutic approaches to control hypertension and slow the progression of renal function decline. Renal denervation modifies efferent and afferent renal sympathetic nerve activity and thus addresses an important modifier of both, blood pressure and renal function that has not been adequately addressed by pharmacologic therapies. This article reviews the current evidence on renal denervation in hypertensive patients with CKD. Safety and efficacy data from clinical trials and observational studies are reassuring that renal denervation is emerging as a promising additional treatment option for patients with uncontrolled hypertension and CKD. However, further randomized controlled data are needed to support these findings, particularly in patients with advanced CKD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.