ArticleClinical kidney journal2025
A registry-based retrospective study comparing pre-dialysis care and early outcomes in native vs transplant kidney failure.
Article in Clinical kidney journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
11 authors.
Funding
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Abstract
Background: Starting dialysis is associated with morbidity and mortality. Outcomes for people with failed transplants can be poorer than for people with native kidney failure. We aimed to determine whether dialysis modality, place of initiation and mortality outcomes differed in the first 90 days between people starting dialysis for transplant and native kidney failure. Methods: Retrospective cohort using linked UK Renal Registry data and Hospital Episode Statistics. Modality, place of initiation and outcomes compared with Day 90 for 16 417 adults starting dialysis in England between January 2018 and December 2019. Results: Relative to those with native kidney failure (90.6%), those with transplant failure (9.4%) were younger (median 55.2 vs 66.3 years) and commenced more in-centre haemodialysis [86.8% vs 82.2%, adjusted odds ratio (OR) 1.72, 95% confidence interval (CI) 1.47-2.01; Discussion: UK patients starting dialysis for transplant failure do so at higher eGFRs than those receiving specialist chronic kidney disease care. Those with transplant failure appear disproportionately likely to start as inpatients, receive haemodialysis or die within 90 days. These findings are likely to reflect differences between both patient groups and care pathways. Deeper understanding may inform improvements in care.
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