ArticleCancer management and research2025
Long Non-Coding RNA TPTEP1 Exerts Tumor Suppressive Functions via Sequestering miR-4295 to Regulate Growth Arrest and DNA Damage-Inducible 45α Expression in Acute Myeloid Leukemia.
Article in Cancer management and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Assessing the contributions of noncoding RNAs in acute myeloid leukemia.Blood neoplasia · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Recent evidences show that long non-coding RNA (lncRNA) plays an essential role in physiology and pathophysiology. The purpose of this study was to determine the role and its potential underlying mechanisms of the lncRNA transmembrane phosphatase with tensin homology pseudogene 1 (TPTEP1) in acute myeloid leukemia (AML). Methods: We detected the TPTEP1 and miR-4295 expression levels in AML cells. The vitro effects of TPTEP1 and miR-4295 on AML cells were analyzed. The correlation between miR-4295 and TPTEP1 or Growth arrest and DNA damage-inducible 45α (GADD45α) was confirmed by a luciferase reporter assay and RNA immunoprecipitation. The expression of GADD45α was investigated by Western blotting. Results: TPTEP1 was down-regulated in AML cell lines and AML patients. Ectopic expression of TPTEP1 inhibited AML cells proliferation while promoted cells apoptosis. And we found that silencing miR-4295 produced the similar effect of TPTEP1 overexpression. TPTEP1 regulated the malignant behavior of AML cells by binding to miR-4295. In addition, overexpression of TPTEP up-regulated GADD45α, a direct target of miR-4295 which play a suppressive role in AML cells. Moreover, when AML cell lines were treated with a DNA methylation inhibitor, TPTEP1 expression was up-regulated. Conclusion: This study reveals that the lncRNA TPTEP1 regulates the expression of GADD45α by sponging miR-4295 in AML cells, which may represent a novel therapeutic target for AML.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.