ReviewCureus2025
Evaluation of Trauma-Induced Coagulopathy by Systematic Insights Into Pathophysiology and Advances in Emergency Resuscitation.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Whole blood storage time impairs clot strength with minimal change in functional fibrinogen concentration.Transfusion · 2026Article
- Whole blood becomes increasingly susceptible to tPA-mediated fibrinolysis with storage.The journal of trauma and acute care surgery · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trauma-induced coagulopathy (TIC) exists as a fatal complication that develops from severe injuries and substantially increases patient mortality. Effective knowledge of TIC pathophysiology, together with optimized resuscitation strategies, is fundamental for enhancing patient outcomes. This review system examined TIC mechanisms through an analysis of present-day intervention methods. This systematic research with meta-analysis covered PubMed, Scopus, and Web of Science, together with Google Scholar databases, to review TIC pathophysiology and resuscitation practices. The inclusion of observational and experimental designs occurred by using predetermined selection criteria. Two independent researchers collected data from studies that received quality assessments through the Newcastle-Ottawa Scale (version 2011), along with the Cochrane Risk of Bias Tool (version 2) evaluation. The GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach served as the method for evaluating evidence certainty. The analyzed studies amounted to 11 after meeting the established criteria. Three major mechanisms led to TIC development, including disrupted fibrinolysis function, impaired platelet functioning, and damaged vessel walls. Six studies submitted for meta-analysis demonstrated that coagulation abnormalities, including hypofibrinogenemia and elevated activated protein C, result in adverse outcomes with a pooled HR of 6.3 (95% CI: 3.04-13.05, p < 0.05). The compound variation (I² = 69%) across data points appeared from differences between measurements and experimental conditions used in the studies. This review presents fibrinogen together with thrombin and activated protein C as diagnostic markers for TIC while supporting the use of protocol-based resuscitation. Future research requires several hospitals to participate in trials to establish new treatment protocols and establish uniform biomarker testing procedures in clinical settings.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.