Evidence map›Paper›PMID 40491615›Full record

ArticleCureus2025

Cutaneous Fistula Caused by Metallosis Following Rigid Spinal Fixation: A Rare but Important Diagnostic Consideration.

Gen Yamauchi, Yu Yamamoto, Yusuke Nishimura, Masakazu Takayasu, Ryuta Saito

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gen YamauchiNeurological Surgery, Kasugai Municipal Hospital, Kasugai, JPN.
Yu YamamotoNeurological Surgery, Inazawa Municipal Hospital, Inazawa, JPN.
Yusuke NishimuraNeurological Surgery, Nagoya University Hospital, Nagoya, JPN.
Masakazu TakayasuNeurological Surgery, Inazawa Municipal Hospital, Inazawa, JPN.
Ryuta SaitoNeurological Surgery, Nagoya University Hospital, Nagoya, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metallosis is a rare complication of spinal instrumentation, typically associated with joint arthroplasty or fusionless constructs. Fistula formation due to metallosis is exceptionally uncommon, particularly in cases involving rigid spinal fixation. We report a case of a 48-year-old female patient who developed a cutaneous fistula at the site of a previous thoracic spinal fixation performed for a metastatic spinal tumor. Clinical examination revealed a small granulomatous mass with a fistula. Although dynamic radiographs showed no apparent instability, computed tomography revealed radiolucent halos around the screws in the right T4 and left T3 pedicles, indicating screw loosening. Magnetic resonance imaging demonstrated a sinus tract extending from the skin to the right T3 pedicle screw. Surgical excision of the fistula and hardware revision were performed. Histological analysis confirmed the presence of metal wear debris and a chronic inflammatory response consistent with metallosis. Bacterial cultures were negative. Despite the absence of typical intraoperative signs such as tissue discoloration or necrosis, metallosis was diagnosed pathologically. This case highlights the importance of considering metallosis in the differential diagnosis of unexplained cutaneous lesions overlying spinal instrumentation. Even in the absence of instability or typical intraoperative findings, metallosis may present solely with skin manifestations such as fistula formation. Early recognition is essential for appropriate management.

Indexed as

cutaneous fistulainstrument failuremetallosispedicle screwspinal fixationspine instrumentation

Identifiers

PMID40491615
PMCPMC12146435

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.