ArticleFrontiers in endocrinology2025
Effectiveness, safety, and practicality of intramuscular progesterone in restoring pregnancy outcomes during frozen embryo transfers.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Progestogen supplementation to prevent miscarriage: Evidence and controversies.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To evaluate whether progesterone (P4) supplementation in patients with low serum progesterone levels after normal luteal phase support (LPS) improves pregnancy outcomes in women undergoing frozen embryo transfer (FET). Methods: A retrospective, single-center cohort study including 1301 vitrified-warmed frozen embryo transfer (FET) cycles conducted from May 2021 to July 2023 at Vinmec Times City International Hospital. A total of 696 FET cycles from individual patients were analyzed for pregnancy outcome. Patients with serum P4 level ≥ 10 ng/ml (Normal P4, n=359) continued to receive standard LPS, while those with P4 levels < 10 ng/ml (Rescue P4, n=337) received 50 mg intramuscular P4 injection daily in addition to the standard LPS for 7-10 days. Results: Daily intramuscular P4 effectively restored serum P4 levels to that of the Normal P4 group and resulted in pregnancy outcome comparable to that of patients with P4 levels ≥10 ng/ml. Notably, the efficacy of this protocol was consistent even in very low serum P4 concentrations (< 4ng/ml) and was independent of preimplantation genetic testing for aneuploidy (PGT-A). Conclusion: Intramuscular P4 effectively increased serum P4 levels resulting in pregnancy and neonatal outcomes comparable to those in patients with P4 levels ≥10 ng/ml. This approach provides a safe, effective intervention to improve FET outcomes, supporting the routine inclusion of serum P4 testing and intramuscular P4 rescue in standard FET protocols.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.