ArticleRegenerative therapy2025
A temperature-sensitive chitosan hydrogels loaded with nano-zinc oxide and exosomes from human umbilical vein endothelial cells accelerates wound healing.
Article in Regenerative therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Review
- Review
- Hydrogel-extracellular vesicle engineering delivery system: a promising therapeutic strategy for wound healing.Journal of nanobiotechnology · 2026Review
- Smart Healing for Wound Repair: Emerging Multifunctional Strategies in Personalized Regenerative Medicine and Their Relevance to Orthopedics.Antibiotics (Basel, Switzerland) · 2026Review
- Advanced small extracellular vesicles delivery systems forExtracellular vesicles and circulating nucleic acids · 2026Review
- Stimuli-responsive hydrogels for radiation-induced skin injury: from passive barriers to autonomous drug delivery systems.Regenerative biomaterials · 2026Review
- Pharmacological and Biological Efficacy of Chitosan-Based Materials.International journal of molecular sciences · 2025Review
- Bioengineered nanoparticles for targeted topical delivery in wound healing: advances and future outlook.Nanomedicine (London, England) · 2025Review
- Tellurium-Doped Silanised Bioactive Glass-Chitosan Hydrogels: A Dual Action for Antimicrobial and Osteoconductive Platforms.Polymers · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The suboptimal therapeutic outcomes of diabetic foot ulcers (DFUs) represent a significant global challenge. In recent years, studies have indicated that novel dressings incorporating exosomes (Exos), nanomaterials, and hydrogels following debridement can synergistically promote tissue repair, which has been widely recognized as a promising emerging trend in the treatment of DFUs. In this study, a combination of zinc oxide nanoparticles (ZnO-NPs), Exos, and chitosan (CS) hydrogel (CS/ZnO-NPs@Exos) was applied to the full-thickness cutaneous defects in a diabetic rat model. This CS/ZnO-NPs@Exos hydrogel was applied to the wound site to achieve sustained and long-term release of Exos, allowing the evaluation of its therapeutic effects. This hydrogel significantly improved the wound closure rate in diabetic skin injuries and reduced oedema, erythema and inflammatory exudate at the wound site. These effects were characterized by enhanced re-epithelialization, reduced infiltration of inflammatory cells, increased collagen deposition, and enhanced angiogenesis in the wound area. This may be related to the Exos derived from human umbilical vein endothelial cells (HUVECs), which notably promote the migration and proliferation of fibroblasts. As a result, the CS/ZnO-NPs@Exos hydrogel offers a new therapeutic dressing for the management of diabetic wounds, with the potential to play a crucial role in clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.