SynthesisFrontiers in oral health2025
Hyaluronic acid as a promoter of the healing of post-extraction socket treated with the socket preservation technique: a systematic review.
Synthesis in Frontiers in oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Autogenous Demineralized Dentin Graft With High Molecular Weight Hyaluronic Acid in Ridge Preservation: Pilot Trial.Clinical implant dentistry and related research · 2025Trial
- Effect of platelet-rich fibrin on microperfusion during early socket healing: a randomized controlled clinical trial.Clinical oral investigations · 2025Trial
- Clinical outcomes of a novel technique for the treatment of oroantral fistulas: a 3-year retrospective study.Annals of medicine and surgery (2012) · 2026Article
- Hyaluronic Acid as an Adjunct in Bone Regeneration-A Systematic Review.Biomedicines · 2026Review
- Bone Substitutes in Alveolar Ridge Augmentation: A Narrative Literature Review.Journal of functional biomaterials · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This review examines the role of hyaluronic acid (HA) in enhancing the healing of the post-extraction socket. HA, a naturally occurring glycosaminoglycan in the extracellular matrix, is crucial for wound healing. It promotes tissue repair by stimulating cell migration, adhesion, and proliferation, essential for bone formation. When combined with deproteinized bovine bone mineral (DBBM), HA may improve bone regeneration and reduce resorption, though evidence is still limited. Methods: Three clinical studies were reviewed, assessing primary outcomes such as volumetric bone resorption, linear bone loss, and soft tissue healing. Radiographic evaluations, including cone beam computed tomography (CBCT), were used to quantify bone changes, while clinical assessments were conducted to evaluate soft tissue responses and wound healing over a 4-month follow-up period. Results: Two studies demonstrated that HA, in combination with DBBM, significantly improved bone preservation. These studies found reduced volumetric bone resorption and enhanced bone width retention, with one showing a significant reduction in crestal bone loss ( Conclusions: The results of this review suggest that HA, combined with DBBM, may offer significant benefits in reducing bone resorption and preserving bone width in ARP procedures. However, the impact of HA on soft tissue healing cannot yet be statistically evaluated, highlighting the need for further investigation to optimize its use in clinical practice. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024526628, PROSPERO CRD42024526628.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.