Evidence map›Paper›PMID 40491496›Full record

ArticleiScience2025

IMPDH inhibition induces DNA replication stress and ATR sensitivity in Merkel cell carcinoma.

Julia L Schnabel, Thomas C Frost, Adam C Wang, Varsha Ananthapadmanabhan, Satvik Gurram, Kara M Soroko, Prafulla C Gokhale, James A DeCaprio

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Julia L SchnabelDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Thomas C FrostDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Adam C WangDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Varsha AnanthapadmanabhanDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Satvik GurramDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Kara M SorokoExperimental Therapeutics Core, Dana-Farber Cancer Institute, Boston, MA, USA.
Prafulla C GokhaleExperimental Therapeutics Core, Dana-Farber Cancer Institute, Boston, MA, USA.
James A DeCaprioDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

Funding

Physician Scientist Training in Cancer ResearchT32CA009172 · NCI · DANA-FARBER CANCER INSTITUTE · PI Jennifer R Brown, James A. DeCaprio · 1985 to 2026
$17.1M
PROJECT 4: Interrogating PP2A Signaling in Human CancersP01CA203655 · NCI · DANA-FARBER CANCER INST · PI DECAPRIO, JAMES A. · 2017 to 2021
$8.0M
The DREAM B-Myb-MuvB complex controls sensitivity to DNA replication activators and inhibitorsR35CA232128 · NCI · DANA-FARBER CANCER INST · PI DECAPRIO, JAMES A. · 2019 to 2025
$7.2M
CaNCURE: Cancer Nanomedicine Co-ops For Undergraduate Research ExperiencesR25CA174650 · NCI · NORTHEASTERN UNIVERSITY · PI SRINIVAS SRIDHAR · 2014 to 2026
$3.4M
NCI NIH HHS P01 CA203655NCI NIH HHS R25 CA174650NCI NIH HHS R35 CA232128NCI NIH HHS T32 CA009172
6 · The paper itself

Abstract

The rate-limiting isozyme of

Indexed as

Cancer systems biologyCell biologyHealth sciences

Identifiers

PMID40491496
PMCPMC12148403

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.