Evidence map›Paper›PMID 40491492›Full record

ArticleiScience2025

LIMK1 variants are associated with divergent endocrinological phenotypes and altered exocytosis dynamics.

Irena J J Muffels, Theodore Carter, Holger Rehmann, Sebastiaan J Vastert, Annemarie A Verrijn Stuart, Andreas C Blank, Aurore Garde, Bert van der Zwaag, Iris M De Lange, Jacques C Giltay and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Irena J J MuffelsDepartment of Metabolic Diseases, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.
Theodore CarterDepartment of Biological Sciences, College of Natural Sciences and Mathematics, Denver, CO, USA.
Holger RehmannDepartment of Energy and Biotechnology, Flensburg University of Applied Sciences, Flensburg, Germany.
Sebastiaan J VastertDepartment of Pediatric Rheumatology and Immunology and Center for Translational Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.
Annemarie A Verrijn StuartDepartment of Pediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.
Andreas C BlankDepartment of Pediatric Cardiology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.
Aurore GardeCentre de Génétique et Centre de Référence Maladies Rares, Fédération Hospitalo-Universitaire Médecine Translationnelle et Anomalies du Développement (FHU TRANSLAD), Hôpital d'Enfants, Centre Hospitalier Universitaire de Dijon, Dijon, France.
Bert van der ZwaagDepartment of Medical Genetics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.
Iris M De LangeDepartment of Medical Genetics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.
Jacques C GiltayDepartment of Medical Genetics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.
Koen L I van GassenDepartment of Medical Genetics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.
Klaas KoopDepartment of Metabolic Diseases, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.
Cedric S AsensioDepartment of Biological Sciences, College of Natural Sciences and Mathematics, Denver, CO, USA.
Peter M van HasseltDepartment of Metabolic Diseases, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

LIM kinase 1 (LIMK1) plays a pivotal role in dynamic actin remodeling through phosphorylation of cofilin, thereby regulating exocytosis. We report two individuals harboring

Indexed as

Biological sciencesEndocrinologyFunctional aspects of cell biology

Identifiers

PMID40491492
PMCPMC12146536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.