Evidence map›Paper›PMID 40491476›Full record

ArticleiScience2025

Rajeswaran Mani, Samon Benrashid, Margaret D Templeton, Lawrence J Druhan, Sara L Seegers, Supriya Chakraborty, Sarah E Teague, Scott C Jaros, Hsih-Te Yang, David M Foureau and 7 more

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Rajeswaran ManiDepartment of Hematologic Oncology and Blood Disorders, Atrium Health Levine Cancer Institute, Charlotte, NC 28204, USA.
Samon BenrashidDepartment of Hematologic Oncology and Blood Disorders, Atrium Health Levine Cancer Institute, Charlotte, NC 28204, USA.
Margaret D TempletonDepartment of Hematologic Oncology and Blood Disorders, Atrium Health Levine Cancer Institute, Charlotte, NC 28204, USA.
Lawrence J DruhanDepartment of Hematologic Oncology and Blood Disorders, Atrium Health Levine Cancer Institute, Charlotte, NC 28204, USA.
Sara L SeegersDepartment of Hematologic Oncology and Blood Disorders, Atrium Health Levine Cancer Institute, Charlotte, NC 28204, USA.
Supriya ChakrabortyDepartment of Hematologic Oncology and Blood Disorders, Atrium Health Levine Cancer Institute, Charlotte, NC 28204, USA.
Sarah E TeagueDepartment of Hematologic Oncology and Blood Disorders, Atrium Health Levine Cancer Institute, Charlotte, NC 28204, USA.
Scott C JarosDepartment of Hematologic Oncology and Blood Disorders, Atrium Health Levine Cancer Institute, Charlotte, NC 28204, USA.
Hsih-Te YangCenter for Cancer Biostatistics, Atrium Health Levine Cancer Institute, Charlotte, NC 28204, USA.
David M FoureauImmune Monitoring Laboratory, Atrium Health Levine Cancer Institute, Charlotte, NC 28204, USA.
Nury M SteuerwaldMolecular Biology and Genomics Laboratory, Atrium Health Levine Cancer Institute, Charlotte, NC 28204, USA.
Dhananjaya PalMolecular Targeted Therapeutics, Atrium Health Levine Cancer Institute, Charlotte, NC 28204, USA.
Nilanjan GhoshDepartment of Hematologic Oncology and Blood Disorders, Atrium Health Levine Cancer Institute, Charlotte, NC 28204, USA.
Edward A CopelanDepartment of Hematologic Oncology and Blood Disorders, Atrium Health Levine Cancer Institute, Charlotte, NC 28204, USA.
Donald L DurdenMolecular Targeted Therapeutics, Atrium Health Levine Cancer Institute, Charlotte, NC 28204, USA.
Belinda R AvalosDepartment of Hematologic Oncology and Blood Disorders, Atrium Health Levine Cancer Institute, Charlotte, NC 28204, USA.
Steven I ParkDepartment of Hematologic Oncology and Blood Disorders, Atrium Health Levine Cancer Institute, Charlotte, NC 28204, USA.

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Dual PI3K/BRD4 Inhibitory Chemotype for Maximum Inhibition of MYC and CancerR01CA215651 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DURDEN, DONALD · 2018 to 2023
$2.3M
NCI NIH HHS P30 CA012197NCI NIH HHS R01 CA215651
6 · The paper itself

Abstract

Bcl2 inhibition has excellent antitumor activity against hematologic malignancies. However, the clinical results in lymphomas harboring

Indexed as

CancerMolecular biologyTherapeutics

Identifiers

PMID40491476
PMCPMC12146551

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.