Evidence map›Paper›PMID 40491463›Full record

ArticleERJ open research2025

Real-life characteristics and management of patients with fibrosing interstitial lung disease: INSIGHTS-ILD registry.

Jürgen Behr, Michael Kreuter, Andreas U Guenther, Francesco Bonella, David Pittrow, Christine Pausch, Benjamin Seeliger, Antje Prasse, Dirk Skowasch, Henrike Wilkens and 41 more

Abstract read
In one paragraph

Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

51 authors.

Jürgen BehrDepartment of Medicine V, LMU University Hospital, LMU Munich, Comprehensive Pneumology Center, German Center for Lung Research (DZL), Munich, Germany.
Michael KreuterMainz Center for Pulmonary Medicine, Department of Pneumology, Mainz University Medical Center and Department of Pulmonary, Critical Care and Sleep Medicine, Marienhaus Clinic Mainz, Mainz, Germany.
Andreas U GuentherClinic for Pneumology, University of Giessen Lung Center, Giessen, Germany.ORCID https://orcid.org/0000-0002-2187-0975
Francesco BonellaPneumology Department, Center for Interstitial and Rare Lung Diseases, Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany.ORCID https://orcid.org/0000-0001-7579-9767
David PittrowDepartment for Clinical Pharmacology, Technical University, Dresden, Germany.ORCID https://orcid.org/0000-0003-1136-2616
Christine PauschInnovation Center Real World Evidence, GWT-TUD GmbH, Dresden, Germany.
Benjamin SeeligerPulmonology, Medical School, Hannover, Germany.
Antje PrassePulmonology, Medical School, Hannover, Germany.ORCID https://orcid.org/0000-0002-7336-7458
Dirk SkowaschInternal Medicine II, University Hospital, Bonn, Germany.
Henrike WilkensMedical Clinic V, University Hospital, Bad Homburg, Germany.
Hans-Joachim KabitzKlinikum, Konstanz, Germany.
Hubert WirtzUniversity Hospital, Leipzig, Germany.
Martin ClaussenLungenClinic, Grosshansdorf, Germany.
Christian GrohéClinic for Pneumology - ELK, Berlin, Germany.
Lars HagmeyerClinik for Pneumology and Allergology, Krankenhaus Bethanien, Solingen, Germany.ORCID https://orcid.org/0000-0003-4285-1244
Stephan BudweiserMedical Clinic III, RoMed Klinikum, Rosenheim, Germany.
Ioana AndreicaRheumazentrum Ruhrgebiet, Herne, Germany.
Ulrich NeffKlinikum, Nuernberg, Germany.
Heike BillerLungenClinic, Grosshansdorf, Germany.
Sven GlaeserClinic for Internal Medicine - Pneumology, Vivantes Hospital, Berlin Neukoelln, Germany.
Martin SchwaiblmairInternal Medicine, University Hospital, Augsburg, Germany.
Peter SchrammLungenzentrum München (Bogenhausen-Harlaching), München, Germany.
F Joachim MeyerLungenzentrum München (Bogenhausen-Harlaching), München, Germany.
Karine ThabaretLungenzentrum München (Bogenhausen-Harlaching), München, Germany.
Jens KlotscheEpidemiology, German Rheuma Research Center (DRFZ), Berlin, Germany.
Tobias VeitDepartment of Medicine V, LMU University Hospital, LMU Munich, Comprehensive Pneumology Center, German Center for Lung Research (DZL), Munich, Germany.
Marion FrankenbergerDepartment of Medicine V, LMU University Hospital, LMU Munich, Comprehensive Pneumology Center, German Center for Lung Research (DZL), Munich, Germany.
Lea DrobbeClinic for Internal Medicine - Pneumology, Vivantes Hospital, Berlin Neukoelln, Germany.
Wolfgang GesierichAsklepios Lungenklinik, Gauting, Germany.ORCID https://orcid.org/0000-0001-6707-6358
Bernd SeeseThoraxzentrum Bezirk Unterfranken, Münnerstadt, Germany.
Elaine KochThoraxzentrum Bezirk Unterfranken, Münnerstadt, Germany.
Achim GrünewaldtMedical Clinic I, University Hospital, Frankfurt, Germany.
Philipp MarkartMedizinische Klinik V, Herz-Thorax-Zentrum, Fulda, Germany.
Michael WesthoffZentrum für Pneumologie und Thoraxchirurgie, Lungenklinik, Hemer, Germany.
Matthias HeldKlinikum Würzburg Mitte - Missioklinik, Würzburg, Germany.
Joachim KirschnerCIMS Studienzentrum, Bamberg, Germany.
Julia WälscherDepartment for Clinical Pharmacology, Technical University, Dresden, Germany.
Stephan EisenmannU Klinik und Poliklinik für Innere Medizin I, Universitätsmedizin Halle, Universitätsklinikum, Halle, Germany.ORCID https://orcid.org/0000-0002-0387-0760
Claus NeurohrRBK Lungenzentrum, Stuttgart, Germany.
Claus-Peter KreutzAsklepios Lungenklinik, Gauting, Germany.
Daniel GrundCharité - Universitätsmedizin, Berlin, Germany.
Sabine HaberlUniversity Hospital, Augsburg, Germany.
Ralf EwertUniversity Hospital, Greifswald, Germany.
Beate StubbeUniversity Hospital, Greifswald, Germany.
Markus PolkeCenter for Interstitial and Rare Lung Diseases, Pneumology, Thoraxklinik, University of Heidelberg, Heidelberg, Germany.
Frank ReichenbergerAugustinum, Lungenklinik, Munich, Germany.
Werner von WulffenAugustinum, Lungenklinik, Munich, Germany.
Ekaterina KraussPneumology Department, Center for Interstitial and Rare Lung Diseases, Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany.ORCID https://orcid.org/0000-0001-8682-4294
Michael WeberZentralklinik Bad Berka, Bad Berka, Germany.
Stephan WalterspacherKlinikum Konstanz und Lehrstuhl für Pneumologie, Universität Witten-Herdecke, Witten, Germany.
Dirk KoschelDepartment of Internal Medicine and Pneumology, Fachkrankenhaus, Coswig, Medical Department I, Division of Pneumology, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study aims to report real-life data on the characteristics and treatment patterns of patients with fibrosing interstitial lung disease (ILD; except idiopathic pulmonary fibrosis) across multiple specialised centres in Germany. Eligibility criteria included ILD affecting >10% of lung parenchyma on high-resolution computed tomography, a single breath diffusion capacity for carbon monoxide ( Methods: As of the interim analysis cut-off, 655 patients (mean±sd age 65.9±11.7 years, 54.5% male) were included. The most common ILD subtypes were fibrosing hypersensitivity pneumonitis (31.2%), fibrosing ILD (22.0%), rheumatoid arthritis and connective tissue disease ILDs (13.0%) and unclassifiable fibrosing ILD (13.0%). Results: Lung function metrics included total lung capacity at 68.3±17.6% predicted, forced vital capacity at 69.8±19.8% predicted, forced expiratory volume in 1 s at 73.7±19.5% predicted and Conclusion: The patient characteristics observed align with those observed in randomised controlled trials and other noninterventional studies. Patients on antifibrotic therapy generally had more severe disease profiles.

Identifiers

PMID40491463
PMCPMC12147108

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.