Evidence map›Paper›PMID 40491247›Full record

Trial reportJournal of pediatric gastroenterology and nutrition2025

Maternal diet and gestational diabetes mellitus modestly influence children's growth during their first 24 months.

Lotta Saros, Tero Vahlberg, Ella Koivuniemi, Noora Houttu, Kristiina Tertti, Nitin Shivappa, James R Hébert, Harri Niinikoski, Kirsi Laitinen

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Journal of pediatric gastroenterology and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01922791 (Placebo-controlled Intervention Study for Maternal and Child Health), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01922791 nacompletednot on this map

Placebo-controlled Intervention Study for Maternal and Child Health

TypeinterventionalSponsorTurku University HospitalRan2013 to 2023Enrolled439ConditionsPregnancy, Obesity, Gestational Diabetes Mellitus, AdiposityArmsComparison of probiotics, fish oil and their combination to placebo
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lotta SarosIntegrative Physiology and Pharmacology Unit, Institute of Biomedicine, University of Turku, Turku, Finland.ORCID https://orcid.org/0000-0001-5090-0662
Tero VahlbergDepartment of Biostatistics, University of Turku and Turku University Hospital, Turku, Finland.ORCID https://orcid.org/0000-0002-4935-3056
Ella KoivuniemiIntegrative Physiology and Pharmacology Unit, Institute of Biomedicine, University of Turku, Turku, Finland.ORCID https://orcid.org/0000-0002-5751-3064
Noora HouttuIntegrative Physiology and Pharmacology Unit, Institute of Biomedicine, University of Turku, Turku, Finland.ORCID https://orcid.org/0000-0002-1350-2187
Kristiina TerttiDepartment of Obstetrics and Gynaecology, University of Turku and Turku University Hospital, Turku, Finland.ORCID https://orcid.org/0000-0001-8950-3103
Nitin ShivappaCancer Prevention and Control Program and Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.ORCID https://orcid.org/0000-0003-0441-8896
James R HébertCancer Prevention and Control Program and Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.ORCID https://orcid.org/0000-0002-0677-2672
Harri NiinikoskiIntegrative Physiology and Pharmacology Unit, Institute of Biomedicine, University of Turku, Turku, Finland.ORCID https://orcid.org/0000-0002-7071-918X
Kirsi LaitinenIntegrative Physiology and Pharmacology Unit, Institute of Biomedicine, University of Turku, Turku, Finland.ORCID https://orcid.org/0000-0001-5245-8118

Funding

Academy of Finland #258606Diabetes Research FoundationJuho Vainio FoundationPäivikki and Sakari Sohlberg FoundationTurku University FoundationTurku University Hospital Expert Responsibility Area
6 · The paper itself

Abstract

objectiveTo evaluate whether diet and gestational diabetes mellitus (GDM) during pregnancy influence children's growth during their first 24 months.

methodsGrowth data of children (n = 378) of women with overweight/obesity were obtained from clinic records (birth, 3, 6, 12 and 24 months), and variables (standard deviation scores (SDS) or percentages) were calculated based on Finnish growth charts. Body composition was measured by air displacement plethysmography (n = 73, 24 months). Diet was assessed (diet quality index, nutrient intakes and diet inflammatory index (DII®)) in early and late pregnancy. GDM was determined by an oral glucose tolerance test.

resultsA good dietary quality in early pregnancy associated positively with the children's height at each time point (adj. mean difference range = 0.28-0.30 SDS, p < 0.05) and head circumference at 12 and 24 months (adj. mean difference range = 0.38-0.42 SDS, p < 0.05). A good dietary quality in late pregnancy associated with a lower fat mass in children (adj. mean difference = -0.69, p < 0.05). A higher DII was correlated with a higher weight at 24 months but a reduced height at each time point (adj. p < 0.05). GDM associated negatively with the children's head circumference at birth and 6 months (adj. mean difference range = -0.43 to [-0.22] SDS, p < 0.05).

conclusionsConsuming a good quality diet during pregnancy associated with a greater infantile height and head circumference but a lower adiposity in 2-year-old children. GDM may lead to a slightly smaller head circumference in early infancy. Mothers with overweight or obesity could support their children's growth by consuming a good quality diet, with low inflammatory potential during pregnancy.

trial registrationClinicalTrials.gov Identifier: NCT01922791, 14 August 2013.

Indexed as

Child DevelopmentDiabetes, GestationalDietMaternal Nutritional Physiological PhenomenaPrenatal Exposure Delayed EffectsAdultBody CompositionBody HeightChild, PreschoolFemaleFinlandHumansInfantInfant, NewbornMaleObesityadiposityhead circumferenceheightmaternal diabetesnutritionoffspring

Identifiers

PMID40491247
PMCPMC12314585

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.