ReviewCNS neuroscience & therapeutics2025
Dual Roles of Autophagy in Radiation-Induced Brain Injury: Mechanistic Insights and Therapeutic Implications.
Review in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Inorganic, Synthetic, Natural, and Innovative Hybrid Hydrogen Sulfide Donors and Inhibitors of Its Biosynthesis in the Treatment of Central and Peripheral Nervous System Injuries: A Systematic Analytical Review.International journal of molecular sciences · 2025Pooled it
- Naoxueshu Oral Liquid Attenuates Early Radiation-Induced Brain Injury in Rats.Brain and behavior · 2026Article
- Aldose reductase inhibition suppresses microglial endoplasmic reticulum stress and ferritinophagy in ischemic stroke.Acta pharmacologica Sinica · 2026Article
- Review
- Autophagy-Modulating Nanomedicine for Glioma: Delivery Barriers, Lysosomal Interactions, and a Flux-Resolved Translational Decision Framework.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundCranial radiotherapy, while essential for treating brain tumors, often leads to radiation-induced brain injury, a debilitating condition marked by cognitive decline and neuronal damage. Autophagy, a key cellular process for recycling damaged organelles and proteins, has emerged as both a protective and detrimental player in radiation-induced brain injury.
methodsThis review systematically explores the dualistic role of autophagy in radiation-induced brain injury, synthesizing insights on its interplay with apoptosis, ferroptosis, neuroinflammation, oxidative stress, the blood-brain barrier, mitophagy, endoplasmic reticulum stress, and mitochondrial biogenesis.
resultsWhile autophagy supports neuronal resilience by mitigating oxidative and inflammatory stress, excessive or dysregulated autophagy can lead to autophagic cell death and exacerbate injury. Pharmacological modulators such as mTOR inhibitors, AMP-activated protein kinase activators, demonstrate therapeutic potential in preclinical settings.
conclusionBy elucidating the mechanistic underpinnings of autophagy in radiation-induced brain injury, this review underscores its dual roles and therapeutic relevance, offering a foundation for targeted interventions that optimize autophagic balance to protect brain function postradiotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.