Evidence map›Paper›PMID 40490827›Full record

ArticleSystematic reviews2025

Evidence map of nutrient interventions for major depression: a systematic review protocol.

Dongbo Zhang, Chenqi Li, Xue Tian, Gen Miao, Wenjing Shi, Hongtao Lu, Yicui Qu, Mengyu Cai, Yuxiao Tang, Hui Shen and 1 more

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Article in Systematic reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dongbo Zhang *Department of Naval Nutrition and Food Hygiene, Naval Medical University, Shanghai, 200433, China.
Chenqi Li *Department of Naval Nutrition and Food Hygiene, Naval Medical University, Shanghai, 200433, China.
Xue Tian *Department of Nutrition, Cangzhou Central Hospital, Cangzhou, Hebei, 061012, China.
Gen MiaoDepartment of Naval Nutrition and Food Hygiene, Naval Medical University, Shanghai, 200433, China.
Wenjing ShiDepartment of Naval Nutrition and Food Hygiene, Naval Medical University, Shanghai, 200433, China.
Hongtao LuDepartment of Naval Nutrition and Food Hygiene, Naval Medical University, Shanghai, 200433, China.
Yicui QuDepartment of Naval Nutrition and Food Hygiene, Naval Medical University, Shanghai, 200433, China.
Mengyu CaiDepartment of Naval Nutrition and Food Hygiene, Naval Medical University, Shanghai, 200433, China.
Yuxiao TangDepartment of Naval Nutrition and Food Hygiene, Naval Medical University, Shanghai, 200433, China. tangyuxiao@smmu.edu.cn.
Hui ShenDepartment of Naval Nutrition and Food Hygiene, Naval Medical University, Shanghai, 200433, China. shenhuicn@126.com.
Biao GaoTeaching and Research Support Center, Naval Medical University, Shanghai, 200433, China. gbdata@163.com.

Funding

Military Key Discipline Construction Projects of China HL21JD1206National Natural Science Foundation of China 81573150Natural Science Research Project from Jiading District of Shanghai JDKW-2024-0013Qiming Star Sailing Special Project under Shanghai's Technology Innovation Action Plan 24YF2758300Shanghai Youth Project for Public Health Research 2024GKQ26the Project of Naval Medical University 2022MS002
6 · The paper itself

Abstract

backgroundDepression severely impacts quality of life globally. While traditional treatments show efficacy, many patients respond poorly. Nutritional interventions demonstrate potential as safe, economical adjunctive therapies. However, current evidence is scattered and heterogeneous, lacking systematic evaluation. This study aims to systematically evaluate evidence for various nutritional interventions in depression and create an evidence gap map (EGM).

methodsWe will conduct a systematic review using the EGM approach. Major medical databases will be searched for relevant studies published up to present. Two independent researchers will screen literature, extract data, and assess evidence quality. Multiple tools will be used for quality assessment: Cochrane Risk of Bias Tool 2.0 for RCTs, ROBINS-I for non-RCTs, Newcastle-Ottawa Scale for observational studies. The GRADE system will be employed for overall evidence grading. EPPI-Reviewer Web will generate the EGM. We will analyze evidence distribution, time trends, and explore impacts of population characteristics and depression subtypes. DISCUSSION: This study will provide critical methodological references for nutritional psychiatry. Expected results include identifying nutrient categories with robust antidepressant evidence, evaluating evidence distribution for different interventions, and exploring differential effects across populations and depression subtypes. Findings will inform individualized nutritional strategies, improve clinical guidelines, and potentially influence public health policies. SYSTEMATIC REVIEW REGISTRATION: CRD42024590644. Date of registration: 30/09/2024.

Indexed as

Dietary SupplementsMajor Depressive DisorderNutrientsHumansQuality of LifeResearch DesignSystematic Reviews as TopicNutrientsDepressionEvidence gap mapNutritionSystematic review

Identifiers

PMID40490827
PMCPMC12147370

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.