ArticleTrials2025
Efficacy of virtual reality hypnosis versus conscious sedation with nitrous oxide in the management of dental anxiety in pediatric dentistry: protocol for a prospective randomized controlled trial.
Article in Trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05167331 (Efficacy of Virtual Reality Hypnosis Versus Nitrous Oxide Inhalation on Children's Anxiety During a Dental Treatment), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Virtual Reality Hypnosis Versus Nitrous Oxide Inhalation on Children's Anxiety During a Dental Treatment : a Randomized Clinical Trial
Who cites it
2 citing papers in PubMed.
- Virtual Reality Goggles as a Distraction Technique for Managing Behavioral Conduct During Pulp Pediatric Dental Treatment: A Systematic Review and Meta-Analysis.Dentistry journal · 2026Review
- Clinical hypnosis in pediatric care: An adjunctive tool or therapeutic illusion.World journal of experimental medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDental anxiety is defined as a persistent and excessive fear of dental treatment. It often leads to interruptions during procedures and, frequently, avoidance of dental care. For patients over the age of 7, nitrous oxide-oxygen inhaled sedation (NOIS) represents one of the most effective and well-established pharmacological approaches to reducing anxiety and pain during dental treatment. Meanwhile, medical hypnosis offers an interesting non-pharmacological alternative by inducing a hypnotic state, potentially serving as a means of sedation to alleviate anxiety or pain. The advancement of virtual reality (VR) technology makes medical hypnosis more accessible to dental practitioners, yielding promising outcomes. To our knowledge, no clinical trial has evaluated the efficacy of medical hypnosis associated with 3D immersive virtual reality devices for pediatric dental procedures.
methodsThis prospective, controlled, single-blind clinical study including anxious patients aged 7 to 10 years old aims to demonstrate non-inferiority of virtual reality approach. Using a split-mouth design, each patient will attend two separate visits for two comparable conservative dental procedures. At the first procedure, they will randomly be assigned to receive either hypnosis via VR or NOIS. The alternative method will be administered during the second visit. The primary outcome is the sedation success based on the completion of the dental procedure. A score of 3 or higher on the Modified Venham Scale noted more than twice ends the session and qualifies as a sedation failure. The secondary outcomes involve assessing children's tolerance and the temperament influence on sedation success. DISCUSSION: This study will evaluate the efficacy of a novel non-pharmacological sedation for the management of anxious children in a dental setting. The results may help practitioners choose the appropriate anxiolytic therapeutic option, based on different psychometric and temperament parameters.
trial registrationClinicalTrials.gov NCT05167331. Registered on December 22, 2021.
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