Evidence map›Paper›PMID 40490755›Full record

ArticleBMC complementary medicine and therapies2025

Anti-oxidative effect of Salvia miltiorrhiza Bunge fermented with Shiraia bambusicola Henn. against H

Qiaona Wang, Canhe Zhu, Zhaoran Song, Yunfa Qiao, Yuefeng Hu, Liyun Hu, Shengjie Li, Renlei Wang

Abstract read
In one paragraph

Article in BMC complementary medicine and therapies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qiaona WangSchool of Ecology and Applied Meteorology, Nanjing University of Information Science & Technology, Nanjing, 210044, People's Republic of China.
Canhe ZhuSchool of Food Science, Nanjing Xiaozhuang University, Nanjing, 211171, People's Republic of China.
Zhaoran SongSchool of Food Science, Nanjing Xiaozhuang University, Nanjing, 211171, People's Republic of China.
Yunfa QiaoSchool of Ecology and Applied Meteorology, Nanjing University of Information Science & Technology, Nanjing, 210044, People's Republic of China.
Yuefeng HuSchool of Food Science, Nanjing Xiaozhuang University, Nanjing, 211171, People's Republic of China.
Liyun HuSchool of Food Science, Nanjing Xiaozhuang University, Nanjing, 211171, People's Republic of China.
Shengjie LiSchool of Food Science, Nanjing Xiaozhuang University, Nanjing, 211171, People's Republic of China. lishengjie@njxzc.edu.cn.
Renlei WangSchool of Ecology and Applied Meteorology, Nanjing University of Information Science & Technology, Nanjing, 210044, People's Republic of China. wrl3501988@163.com.

Funding

Jiangsu Provincial Key Construction Laboratory (No. SuJiaoKe [2024] 3) of Nanjing Xiaozhuang University No. SuJiaoKe [2024] 3
6 · The paper itself

Abstract

purposeThe objective of this investigation was to produce fermented solid-state products of Salvia miltiorrhiza Bunge (SMB) utilizing Shiraia bambusicola Henn. (FSSMB). Additionally, it was intended to further explore toxicity-reducing potential and antioxidant effects of FSSMB ethanol extract against H

methodsPC12 cells were pre-treated with SMB or FSSMB ethanol extract for 24 h, followed by exposure to 1 mmol/L H

resultsHere, we found that FSSMB exhibited lower cytotoxicity compared to SMB in PC12 cells, and FSSMB instead of SMB significantly increased cell viability in H

conclusionsOur study explores a new biological transformation approach through solid-state fermentation (SSF) with Shiraia bambusicola Henn. on SMB. This study demonstrated that the SSF may reduce the cytotoxicity and enhance the antioxidant capacity of SMB in PC12 cells, thus paving the way for safer and more efficacious applications in the future. FSSMB may be an effective substitute for traditional Chinese medicine SMB for resistance to oxidative stress.

Indexed as

AntioxidantsAscomycotaOxidative StressPlant ExtractsSalvia miltiorrhizaAnimalsCell SurvivalFermentationHydrogen PeroxidePC12 CellsRatsReactive Oxygen SpeciesAntioxidantsHydrogen PeroxidePlant ExtractsReactive Oxygen SpeciesCytotoxicityMAPKOxidative stressSalvia miltiorrhiza BungeSolid-state fermentation

Identifiers

PMID40490755
PMCPMC12147247

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.