Evidence map›Paper›PMID 40490725›Full record

Trial reportBMC oral health2025

Effect of silver diamine fluoride and nanosilver on salivary bacterial counts in children with early childhood caries: a randomized controlled clinical trial.

Nour Ammar, Magda M El-Tekeya, Dalia M Talat, Sara Essa, Marwa M Essawy, Jan Kühnisch, Hams Hamed, Nouran Nabil, Samar El Achy, Maha El Tantawi

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05221749 (The Antibacterial Effect of Nanosilver Fluoride in Relation to Caries Activity in Primary Teeth), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05221749 phase3terminatednot on this map

The Antibacterial Effect of Nanosilver Fluoride in Relation to Caries Activity in Primary Teeth: a Randomized Controlled Clinical Trial

TypeinterventionalSponsorNour Ammar, BDSRan2022 to 2022Enrolled50ConditionsPrimary Teeth, Microbial Colonization, Caries, Dental Caries in ChildrenArmsNanosilver Fluoride (NSF), Silver diamine fluoride
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nour AmmarDepartment of Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Alexandria University, Alexandria, 21521, Egypt. nour.ammar@alexu.edu.eg.
Magda M El-TekeyaDepartment of Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Alexandria University, Alexandria, 21521, Egypt.
Dalia M TalatDepartment of Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Alexandria University, Alexandria, 21521, Egypt.
Sara EssaDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Alexandria University, Alexandria, 21521, Egypt.
Marwa M EssawyDepartment of Oral Pathology, Faculty of Dentistry, Alexandria University, Alexandria, 21521, Egypt.
Jan KühnischDepartment of Conservative Dentistry and Periodontology, University Hospital, Ludwig-Maximilian University of Munich, 80336, Munich, Germany.
Hams HamedDepartment of Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Alexandria University, Alexandria, 21521, Egypt.
Nouran NabilDepartment of Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Alexandria University, Alexandria, 21521, Egypt.
Samar El AchyCenter of Excellence for Research in Regenerative Medicine and Applications (CERRMA), Faculty of Medicine, Alexandria University, Alexandria, 21521, Egypt.
Maha El TantawiDepartment of Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Alexandria University, Alexandria, 21521, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSilver diamine fluoride (SDF) is indicated for the management of early childhood caries (ECC). Similarly, nanosilver fluoride (NSF) is effective against caries. However, there are limited comparisons between both agents, especially regarding their antibacterial effect. This randomized controlled clinical trial aimed to compare the effects of SDF and NSF on salivary bacterial counts in children with ECC.

methodsFifty 4-6-year-olds presenting with active dentin caries (ICDAS code 5) in primary teeth were randomly allocated to two groups. Streptococcus mutans (S. mutans) and Lactobacilli in unstimulated saliva were cultivated on differential media and counted as colony-forming units. Followed by the application of either 38% SDF or NSF. Saliva samples were recollected after one month. The legal guardians completed a detailed questionnaire assessing their child's dental hygiene habits, dental pain experience, and socioeconomic background. Multivariable binary logistic regression was used to assess the effects of both agents on bacterial counts while accounting for confounders.

resultsThe mean age of participants was 4.8 ± 0.8 years, with the majority (96%, N = 48) presenting with severe ECC. There were no statistically significant differences between the two groups regarding age, sex, dmft score, socioeconomic background, dental hygiene habits, or dental experience. After one month, within-group analysis showed a significant reduction in S. mutans only in the NSF group (p = 0.002) and significant decreases in Lactobacilli counts in both SDF and NSF groups (p < 0.05). However, between-group comparisons revealed no significant differences in the reduction of S. mutans (1.4% and 6.0%, respectively, p = 0.192) or Lactobacilli counts (6.0% and 6.0%, respectively, p = 0.754). Regression analyses revealed non-significant odds of reduced bacterial counts after NSF application compared to SDF.

conclusionAfter one application, children with ECC showed significant decrease in salivary bacteria, with no difference between the two agents regarding their antibacterial effect. NSF can serve as a viable option in ECC management in that it provides comparable antibacterial effects to 38% SDF without inducing tooth discoloration. This trial was prospectively registered on the clinicaltrials.gov registry with ID: NCT05221749 on 03/02/2022.

Indexed as

Bacterial LoadCariostatic AgentsDental CariesFluorides, TopicalMetal NanoparticlesSalivaSilver CompoundsChildChild, PreschoolFemaleHumansLactobacillusMaleQuaternary Ammonium CompoundsStreptococcus mutansCariostatic AgentsFluorides, TopicalQuaternary Ammonium CompoundsSilver Compoundssilver diamine fluorideDental cariesEarly childhood cariesNanoparticlesNano silverPediatric dentistryPrimary teethSalivaStreptococci

Identifiers

PMID40490725
PMCPMC12150551

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.