Evidence map›Paper›PMID 40490679›Full record

ArticleACS infectious diseases2025

Inhibitors of the Bacterioferritin Ferredoxin Complex Dysregulate Iron Homeostasis and Kill

Alexanndra M Behm, Huili Yao, Emmanuel C Eze, Suliat A Alli, Simon D P Baugh, Ebenezer Ametsetor, Kendall M Powell, Kevin P Battaile, Steve Seibold, Scott Lovell and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Revisiting the Fight AgainstAntibiotics (Basel, Switzerland) · 2026
    Review
  4. Norepinephrine derepresses the Fur regulon ofJournal of bacteriology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alexanndra M BehmDepartment of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Huili YaoDepartment of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Emmanuel C EzeDepartment of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Suliat A AlliDepartment of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Simon D P BaughFox Chase Therapeutics Discovery, Inc, Doylestown, Pennsylvania 18902, United States.
Ebenezer AmetsetorDepartment of Chemistry, Oklahoma State University, Stillwater, Oklahoma 74078, United States.
Kendall M PowellDepartment of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Kevin P BattaileNew York Structural Biology Center, New York, New York 10027, United States.ORCID 0000-0003-0833-3259
Steve SeiboldProtein Structure and X-ray Crystallography Laboratory, Del Shankel Structural Biology Center, University of Kansas, Lawrence, Kansas 66047, United States.
Scott LovellProtein Structure and X-ray Crystallography Laboratory, Del Shankel Structural Biology Center, University of Kansas, Lawrence, Kansas 66047, United States.
Richard A BunceDepartment of Chemistry, Oklahoma State University, Stillwater, Oklahoma 74078, United States.ORCID 0009-0003-7927-5655
Allen B ReitzFox Chase Therapeutics Discovery, Inc, Doylestown, Pennsylvania 18902, United States.
Mario RiveraDepartment of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, United States.ORCID 0000-0002-5692-5497

Funding

Small molecules for perturbing iron homeostasis in bacterial biofilmsR01AI169344 · NIAID · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI Mario Rivera · 2022 to 2026
$3.7M
An Eiger2 XE 9M detector for the NYSBC-operated NYX beamline at NSLS-IIS10OD030394 · OD · NEW YORK STRUCTURAL BIOLOGY CENTER · PI BATTAILE, KEVIN P · 2021 to 2021
$1.8M
NIAID NIH HHS R01 AI169344NIH HHS S10 OD030394
6 · The paper itself

Abstract

In

Indexed as

Acinetobacter baumanniiAnti-Bacterial AgentsBacterial ProteinsBiofilmsCytochrome b GroupFerredoxinsFerritinsHomeostasisIronPseudomonas aeruginosaBinding SitesAnti-Bacterial AgentsBacterial ProteinsbacterioferritinCytochrome b GroupFerredoxinsFerritinsIronantibioticbacterioferritinbiofilmiron homeostasisiron storage

Identifiers

PMID40490679
PMCPMC12261321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.