Evidence map›Paper›PMID 40490669›Full record

ArticleEndocrine2025

Surgical decision in patients with primary aldosteronism based on adrenal veins aldosterone not corrected by cortisol.

Furong He, Xizi Zhang, Yiyang Fu, Jun Yang, Zhipeng Du, Ying Song, Jinbo Hu, Qianna Zhen, Yifan He, Qifu Li and 3 more

Abstract read
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Article in Endocrine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Furong HeDepartment of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xizi ZhangDepartment of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yiyang FuDepartment of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jun YangDepartment of Medicine, Monash University, Clayton, Australia.
Zhipeng DuDepartment of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ying SongDepartment of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jinbo HuDepartment of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Qianna ZhenDepartment of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yifan HeDepartment of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Qifu LiDepartment of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Wenwen HeDepartment of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 3nishuideyu3@163.com.
Shumin YangDepartment of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. ysm@hospital.cqmu.edu.cn.
Chongqing Primary Aldosteronism Study (CONPASS) Group

Funding

Joint Medical Research Project of Chongqing Science and Technology Commission & Chongqing Health and Family Planning Commission 2022ZDXM003National Natural Science Foundation of China U21A20355The Chongqing Science and Health Joint Medical Research Project CSTB2024TIAD-KPX0039The Chongqing Technology Innovation and Application Development Special Key Project 2025GGXM004The National Key Research and Development Project 2022YFC2505301The National Key Research and Development Project 2022YFC2505302
6 · The paper itself

Abstract

backgroundCortisol-corrected aldosterone concentration is used to interpret adrenal venous sampling (AVS) results to identify the subtype of primary aldosteronism. Whether AVS could be interpreted using aldosterone without cortisol correction is unclear. PURPOSE: To evaluate the accuracy of plasma aldosterone concentration (PAC) and aldosterone ratio (PAC of the higher side divided by PAC of the lower side) of the adrenal veins for the diagnosis of unilateral PA (UPA).

methodsA retrospective study was conducted in PA patients who underwent bilaterally successful AVS. Area under the receiver operating characteristic curve (AUC), specificity and sensitivity of PAC and aldosterone ratio of adrenal veins in non-stimulated and adrenocorticotropic hormone (ACTH) - stimulated AVS were calculated.

results323 patients with UPA and 122 with bilateral PA were included. Under non-ACTH stimulated AVS, AUC of PAC and aldosterone ratio to diagnose UPA were 0.86 (95%CI 0.83-0.89) and 0.84 (95%CI 0.80-0.88), respectively. The specificity was 90%, with sensitivity of 59%, when using PAC cutoff of 1012.8 ng/dL to diagnose UPA. The specificity was 90%, with sensitivity of 65%, when using aldosterone ratio cutoff of 6.84 to diagnose UPA. Under ACTH stimulated AVS, PAC and aldosterone ratio showed similar accuracy to diagnose UPA. The specificity was 90%, with sensitivity of 60%, when using PAC cutoff of 4008.3 ng/dL to diagnose UPA. The specificity was 90%, with sensitivity of 80%, when using aldosterone ratio cutoff of 4.77 to diagnose UPA.

conclusionPAC and aldosterone ratio of the adrenal veins can be used to diagnose UPA during non-stimulated and ACTH-stimulated AVS.

Indexed as

Adrenal GlandsAldosteroneHydrocortisoneHyperaldosteronismAdrenocorticotropic HormoneAdultAgedClinical Decision-MakingFemaleHumansMaleMiddle AgedRetrospective StudiesSensitivity and SpecificityVeinsAdrenocorticotropic HormoneAldosteroneHydrocortisoneAdrenal venous samplingAldosterone ratio of adrenal veinsPAC of adrenal veinsPrimary aldosteronismUnilateral primary aldosteronism

Identifiers

PMID40490669

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.