Evidence map›Paper›PMID 40490660›Full record

ArticleMolecular neurobiology2025

Nicotine Attenuates Pathogenesis of Parkinson's Disease via α7-nAChR-Mediated Lipid Metabolic Reprogramming and Anti-inflammatory Signaling.

Jingjing Yang, Yingyan Li, Hongjuan Wang, Xin Li, Huan Chen, Hongwei Hou, Qingyuan Hu

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jingjing Yang *Beijing Life Science Academy, Beijing, 102209, China.
Yingyan Li *Beijing Life Science Academy, Beijing, 102209, China.
Hongjuan WangBeijing Life Science Academy, Beijing, 102209, China.
Xin LiBeijing Life Science Academy, Beijing, 102209, China. lixin@blsa.com.cn.
Huan ChenBeijing Life Science Academy, Beijing, 102209, China. hunny_ch@163.com.
Hongwei HouBeijing Life Science Academy, Beijing, 102209, China. qsfctc@163.com.
Qingyuan HuBeijing Life Science Academy, Beijing, 102209, China.

Funding

Science and Technology Project of Beijing Life Science Academy 2023000CA0040
6 · The paper itself

Abstract

Nicotine-an abundant tobacco alkaloid-has been epidemiologically linked to a lower incidence of Parkinson's disease (PD). In a 6‑hydroxydopamine (6‑OHDA) rat model, we found that chronic nicotine (1.5 mg kg

Indexed as

alpha7 Nicotinic Acetylcholine ReceptorAnti-Inflammatory AgentsLipid MetabolismNicotineParkinson DiseaseSignal TransductionAnimalsCell Line, TumorHumansInflammationMaleMetabolic ReprogrammingOxidopamineRatsRats, Sprague-Dawleyalpha7 Nicotinic Acetylcholine ReceptorAnti-Inflammatory AgentsNicotineOxidopamine6-OHDABDNFLipid metabolismNeuroinflammationNicotineParkinson’s diseaseα7-nAChR

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.