ArticleEuropean journal of pediatrics2025
Volume ratio of pulmonary lesions as a novel indicator for predicting the occurrence of plastic bronchitis in children with Mycoplasma pneumoniae pneumonia.
Article in European journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Risk factors associated with plastic bronchitis in children with severeJournal of thoracic disease · 2026Article
- Early prediction of plastic bronchitis in pediatric patients withFrontiers in cellular and infection microbiology · 2026Article
- Clinical features and risk factors of plastic bronchitis in Mycoplasma pneumoniae pneumonia children with pulmonary consolidation: a prospective cohort study.Frontiers in pediatrics · 2026Article
- Clinical risk factors and a predictive nomogram for mechanical ventilation in pediatric patients with infection-related plastic bronchitis.BMC infectious diseases · 2025Article
- Risk Factor Analysis of Mycoplasma pneumoniae Pneumonia Complicated With Plastic Bronchitis in Children: A Single-Center Retrospective Study.The clinical respiratory journal · 2025Article
- Pulmonary lesion volume ratio and laboratory parameters as risk factors for plastic bronchitis in pediatric refractory Mycoplasma pneumoniae pneumonia.BMC pediatrics · 2025Article
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Abstract
Plastic bronchitis (PB) is one of the pulmonary complications associated with Mycoplasma pneumoniae pneumonia (MPP). Early diagnosis of PB is challenging, and delayed removal of bronchial casts may lead to an increased risk of poor prognosis in MPP patients. This study aims to investigate the role of the volume ratio of pulmonary lesions, as evaluated by chest CT, in identifying PB in children with MPP. A total of 273 children diagnosed with MPP and treated with fiberoptic bronchoscopy (FB) were included in the study. The children were divided into two groups based on the presence or absence of PB. Clinical characteristics and lung volume data analyzed using 3D Slicer software were compared between the two groups. The PB group showed significantly higher levels of C-reactive protein (CRP), procalcitonin (PCT), D-dimer, lactate dehydrogenase (LDH), aspartate transaminase (AST), and alanine transaminase (ALT), as well as lower lymphocyte counts (P < 0.001). The proportion of pleural effusion, as assessed by chest CT, was also significantly higher in the PB group compared to the non-PB group (63.41%vs. 25.86%; P < 0.001). Regarding treatments, the PB group had a higher proportion of multiple FB therapies (85.37% vs. 16.81%), secondary antimicrobials use (46.34% vs. 10.43%), corticosteroid resistance (68.29% vs. 12.50%), and intravenous immunoglobulin (IVIG) treatment (29.27% vs .4.31%) compared to the non-PB group (P < 0.001). The volume ratio of pulmonary lesions was significantly higher in the PB group than in the non-PB group (P < 0.001). Using a threshold of more than 8.23%, the sensitivity and specificity for identifying PB were 95.12% and 77.16%, respectively, with an excellent AUC value (0.920, 95% CI 0.879-0.962). In all MPP patients, a positive linear relationship was observed between MP-DNA copy grade and the volume ratio of pulmonary lesions, with a high degree of correlation (r
conclusionsThe volume ratio of pulmonary lesions may serve as a promising indicator for identifying PB in children with MPP. WHAT IS KNOWN: • Mycoplasma pneumoniae pneumonia (MPP) can lead to plastic bronchitis (PB). WHAT IS NEW: • The volume ratio of pulmonary lesions based on chest CT can predict the occurrence of MPP-associated PB.
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