Evidence map›Paper›PMID 40490527›Full record

ArticleGenes and immunity2025

Tumor-associated macrophages-induced lncRNA RP11-627G18.1 promotes breast cancer metastasis.

Luna Hong, Yijiao Huang, Fengzhan Ye, Shan Wang, Yongqiang Wang, Jie Luo, Zongjiang Zhou, Junpu Wang, Xiaoqing Yuan, Nan Zhou

Abstract read
PubMed Publisher
In one paragraph

Article in Genes and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. The Long Non-coding RNA Landscape of Endurance Exercise Training.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Luna Hong *Department of Pulmonary and Critical Care Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, P. R. China.
Yijiao Huang *Department of Pulmonary and Critical Care Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, P. R. China.
Fengzhan Ye *Department of Pulmonary and Critical Care Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, P. R. China.
Shan WangDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, P. R. China.
Yongqiang WangGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, P. R. China.
Jie LuoDepartment of Clinical Laboratory, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, P. R. China.
Zongjiang ZhouDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, P. R. China.
Junpu WangDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, P. R. China. wang-jp2013@csu.edu.cn.ORCID 0000-0002-3193-1268
Xiaoqing YuanGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, P. R. China. yuanxq7@mail.sysu.edu.cn.ORCID 0000-0002-5376-3162
Nan ZhouDepartment of Research, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, P. R. China. nanzhou@gzhmu.edu.cn.ORCID 0000-0002-0393-316X

Funding

China Postdoctoral Science Foundation 2023M744022National Natural Science Foundation of China (National Science Foundation of China) 81803636National Natural Science Foundation of China (National Science Foundation of China) 82302012Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2018A0303130329Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2023A1515140033Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2024A1515030038
6 · The paper itself

Abstract

Tumor-associated macrophages (TAMs) promote the transition of breast cancer cells from an epithelioid to a mesenchymal phenotype (EMT) and facilitate breast cancer metastasis, but the role of lncRNA in this process is poorly understood. We employed bioinformatics analysis to identify TAMs-related lncRNAs involved in EMT, migration and metastasis of breast cancer cells. LncRNA RP11-627G18.1 was identified as a TAMs-induced lncRNA in breast cancer cells and was further evaluated using RT-qPCR. The roles of lncRNA RP11-627G18.1 in EMT and migration were further explored using RNA interference, western blot, immunofluorescence, wound healing, and transwell assays. We discovered that TAMs-related lncRNA RP11-627G18.1 is positively correlated with EMT, metastasis, and poor prognosis in breast cancer. In vitro studies showed that lncRNA RP11-627G18.1 was induced by TAMs in breast cancer cells, accompanied by enhanced EMT and migration. Knockdown of lncRNA RP11-627G18.1 reversed EMT and inhibited the migration of breast cancer cells. TAMs-induced lncRNA RP11-627G18.1 promoted EMT, migration of breast cancer cells, and tumor metastasis, suggesting it as a promising biomarker and therapeutic target for breast cancer.

Indexed as

Breast NeoplasmsRNA, Long NoncodingTumor-Associated MacrophagesCell Line, TumorCell MovementEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticHumansNeoplasm MetastasisRNA, Long Noncoding

Identifiers

PMID40490527

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.