ArticleNature genetics2025
An atypical NLR pair TdCNL1/TdCNL5 from wild emmer confers powdery mildew resistance in wheat.
Article in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Phylogenetic and Functional Analyses of WheatBiology · 2026Article
- Identification of candidate gene for the wheat powdery mildew resistance gene Pm40 by bulked segregant analysis coupled with whole-genome sequencing (BSA-seq).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- A pangenome of tetraploid wheat reveals the genetic architecture underlying domestication and genomic diversity for breeding.Nature genetics · 2026Article
- Characterization of Durum-Einkorn Amphiploids for Introgression of Powdery Mildew Resistance from Einkorn into Common Wheat.Pathogens (Basel, Switzerland) · 2026Article
- Genome-Wide Identification of theBiology · 2026Article
- Fine mapping of a powdery mildew resistance gene PmCWI16926 from cultivated emmer wheat.Communications biology · 2026Article
- Fine mapping and candidate gene dissection of the wheat powdery mildew resistance gene PmPBDH.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- A neighboring NLR negatively regulates the wheat broad-spectrum resistance protein encoded by Pm21.Science China. Life sciences · 2026Article
- The pyramiding ofFrontiers in plant science · 2026Article
- Characterization and genetic dissection of the powdery mildew resistance in cultivated emmer wheat accession L424.BMC plant biology · 2025Article
- An NLR pair in the Pm68 locus confers powdery mildew resistance in durum and common wheat.Nature communications · 2025Article
- Two complementary NLRs from wild emmer wheat confer powdery mildew resistance.Nature communications · 2025Article
- Paired NLRs originated from Triticum dicoccoides coordinately confer resistance to powdery mildew in wheat.Nature communications · 2025Article
- Harnessing primary, secondary and tertiary genepools for durable wheat disease resistance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- Genome-Wide Characterization Highlights Key Roles for Bread Wheat MLO Genes in Powdery Mildew and Abiotic Stresses.Rice (New York, N.Y.) · 2025Article
- Identification and characterization of a novel powdery mildew resistance gene PmCWI45575 in wild emmer wheat.BMC plant biology · 2025Article
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28 authors.
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Abstract
Resistance to wheat powdery mildew is commonly mediated by individual resistance proteins, most of which encode nucleotide-binding leucine-rich repeat (NLR) receptors. Here we report that the powdery mildew resistance gene MLIW170/PM26 in wild emmer and bread wheat derivatives is determined by a genetically linked atypical NLR pair TdCNL1/TdCNL5. Map-based cloning and PacBio HiFi long-read sequencing revealed that TdCNL1 encodes an atypical coiled-coil-domain-containing NLR protein (CNL) fused with a new potassium-dependent sodium-calcium exchanger integrated domain, whereas TdCNL5 encodes a canonical CNL protein. Mutagenesis and virus-induced gene silencing experiments indicated that both TdCNL1 and TdCNL5 are essential for powdery mildew resistance. Transgenic plants with TdCNL1 alone or TdCNL1/TdCNL5 together show resistance, whereas Fielder with TdCNL5 alone was susceptible. Geographically, MLIW170/PM26 occurs in a few Southern populations of wild emmer wheat. Our study highlights an atypical NLR pair coordinately regulating powdery mildew resistance and provides a diversified resistance gene resource for wheat improvement.
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