ArticleNature genetics2025
Coordinated function of paired NLRs confers Yr84-mediated stripe rust resistance in wheat.
Article in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- QTL Mapping for Leaf Rust Resistance in a Wheat Recombinant Inbred Line Population of Liang66-S/Hengmai28.Plants (Basel, Switzerland) · 2026Article
- A transmembrane protein confers the Yr26/Yr24/YrCH42/YrG22-mediated stripe rust resistance in wheat.Nature communications · 2026Article
- Two atypical resistance proteins confer plant resistance to Melanaphis sorghi in sorghum.Plant communications · 2026Article
- A tetraploid wheat pangenome reveals genomic variation and domestication footprints.Nature genetics · 2026Article
- A pangenome of tetraploid wheat reveals the genetic architecture underlying domestication and genomic diversity for breeding.Nature genetics · 2026Article
- From QTL to candidate genes: a data-driven approach to unravel the genetic architecture of yellow rust resistance in central European wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Watkins wheat landraces: a treasure of stripe rust resistance alleles identified using multi-model association analyses.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Domain-less defenders: evolutionary innovations and agricultural promise of noncanonical NLRs.aBIOTECH · 2026Article
- Genetic analysis and mapping of adult plant stripe rust resistance loci in CIMMYT wheat 'Kijil' under Mexican and Chinese field environments.PLoS genetics · 2026Article
- The emerging role of kinase fusion proteins in cereal immunity.Nature genetics · 2026Review
- Fine mapping and candidate gene dissection of the wheat powdery mildew resistance gene PmPBDH.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Identification of stripe rust adult plant resistance genes in the hard winter wheat cultivar Baker's Ann.The plant genome · 2026Article
- A neighboring NLR negatively regulates the wheat broad-spectrum resistance protein encoded by Pm21.Science China. Life sciences · 2026Article
- The pyramiding ofFrontiers in plant science · 2026Article
- Paired NLRs originated from Triticum dicoccoides coordinately confer resistance to powdery mildew in wheat.Nature communications · 2025Article
- Two complementary NLRs from wild emmer wheat confer powdery mildew resistance.Nature communications · 2025Article
- Harnessing primary, secondary and tertiary genepools for durable wheat disease resistance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- Genetic Basis Identification of aPlants (Basel, Switzerland) · 2025Article
- An atypical NLR pair TdCNL1/TdCNL5 from wild emmer confers powdery mildew resistance in wheat.Nature genetics · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cloning of resistance genes expands our understanding of their function and facilitates their deployment in breeding. Here we report the cloning of two genes from wild emmer wheat (Triticum turgidum ssp. dicoccoides) underlying Yr84-mediated stripe rust resistance using a combination of fine mapping, long-read sequencing and mutation-induced functional validation. In contrast to all previously cloned stripe rust genes, the incompletely dominant Yr84 phenotype is conferred through the coordinated function of paired nucleotide-binding leucine-rich repeat (NLR) genes CNL and NL. We reason that based on their genomic organization, annotation, expression profiles and predicted protein structure, CNL functions as a sensor NLR, responsible for effector recognition, and NL acts as a helper NLR, initiating downstream resistance cascades. Both the CNL and NL lack an integrated domain(s) previously implicated in effector recognition by paired NLRs; therefore, these findings contribute insights into the structure and molecular mechanisms of the function of plant paired NLRs.
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