ArticleHuman brain mapping2025
Microstructural Characterization of Short Association Fibers Related to Long-Range White Matter Tracts in Normative Development.
Article in Human brain mapping, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Congenital blindness reduces myelination in human visual cortex.Science advances · 2026Article
- Modeling a Shared Reality of Tractography through Varied Structural Imaging.bioRxiv : the preprint server for biology · 2026Article
- Modeling a Shared Reality of Tractography through Varied Structural Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
Short association fibers (SAFs) in the superficial white matter play a key role in mediating local cortical connections but have not been well-studied as innovations in whole-brain diffusion tractography have only recently been developed to study superficial white matter. Characterizing SAFs and their relationship to long-range white matter tracts is crucial to advance our understanding of neurodevelopment during the period from childhood to young adulthood. This study aims to (1) map SAFs in relation to long-range white matter tracts, (2) characterize typical neurodevelopmental changes across these white matter pathways, and (3) investigate the relationship between microstructural changes in SAFs and long-range white matter tracts. Leveraging a cohort of 616 participants ranging in age from 5.6 to 21.9 years old, we performed quantitative diffusion tractography and advanced diffusion modeling with diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI). Robust linear regression models were applied to analyze microstructural features, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), radial diffusivity (RD), intracellular volume fraction (ICVF), isotropic volume fraction (ISOVF), and orientation dispersion index (ODI). Our results reveal that both SAFs and long-range tracts exhibit similar overall developmental patterns, characterized by negative associations of MD, AD, and RD with age and positive associations of FA, ICVF, ISOVF, and ODI with age. Notably, FA, AD, and ODI exhibit significant differences between SAFs and long-range tracts, suggesting distinct neurodevelopmental trajectories between superficial and deep white matter. In addition, significant differences were found in MD, RD, and ICVF between males and females, highlighting variations in neurodevelopment. This normative study provides insights into typical microstructural changes of SAFs and long-range white matter tracts during development, laying a foundation for future research to investigate atypical development and dysfunction in disease pathology.
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Registered trials
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