Evidence map›Paper›PMID 40490361›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Role of Hypothalamic CRH Neurons in Regulating the Impact of Stress on Memory and Sleep.

Alyssa Wiest, John J Maurer, Kevin T Beier, Franz Weber, Shinjae Chung

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Neurotensin in the extended amygdala maintains wakefulness in novel environments.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alyssa WiestDepartment of Neuroscience, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
John J MaurerDepartment of Neuroscience, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Kevin T BeierDepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, California 92617.ORCID 0000-0002-4934-1338
Franz WeberDepartment of Neuroscience, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.ORCID 0000-0002-4541-4907
Shinjae ChungDepartment of Neuroscience, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 shinjaec@pennmedicine.upenn.edu.

Funding

PREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM008076 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BLENDY, JULIE A · 1985 to 2023
$10.8M
Neural basis underlying the impact of stress on sleepR01MH136491 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI CHUNG, SHINJAE · 2024 to 2024
$588k
Neuronal and homeostatic regulation of sleep and wake by corticotropin-releasing hormone neurons in the paraventricular nucleus of the hypothalamusF31HL160451 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WIEST, ALYSSA N · 2022 to 2024
$118k
NHLBI NIH HHS F31 HL160451NIGMS NIH HHS T32 GM008076NIMH NIH HHS R01 MH136491
6 · The paper itself

Abstract

Stress profoundly affects sleep and memory processes. Stress impairs memory consolidation and, similarly, disruptions in sleep compromise memory functions. Yet, the neural circuits underlying stress-induced sleep and memory disturbances are still not fully understood. Here, we show that activation of corticotropin-releasing hormone neurons in the paraventricular nucleus of the hypothalamus (CRH

Indexed as

Corticotropin-Releasing HormoneHypothalamusMemoryMemory DisordersNeuronsParaventricular Hypothalamic NucleusSleepStress, PsychologicalAnimalsMaleMiceMice, Inbred C57BLRestraint, PhysicalCorticotropin-Releasing Hormone

Identifiers

PMID40490361
PMCPMC12225598

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.