Evidence map›Paper›PMID 40490354›Full record

ArticleGenes & development2025

ELAV mediates circular RNA biogenesis in neurons.

Carlos Alfonso-Gonzalez, Mengjin Shi, Sakshi Gorey, Sarah Holec, Judit Carrasco, Michael Rauer, Stylianos Tsagkris, Fernando Mateos, Valérie Hilgers

Abstract read
In one paragraph

Article in Genes & development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carlos Alfonso-Gonzalez *Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany; hilgers@ie-freiburg.mpg.de carlos.alfonso@embl.de.
Mengjin Shi *Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Sakshi GoreyMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Sarah HolecMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Judit CarrascoMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Michael RauerMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Stylianos TsagkrisMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Fernando MateosMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Valérie HilgersMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany; hilgers@ie-freiburg.mpg.de carlos.alfonso@embl.de.ORCID 0000-0002-4551-0931

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
NIH HHS P40 OD018537
6 · The paper itself

Abstract

Circular RNAs (circRNAs) arise from back-splicing of precursor RNAs and accumulate in the nervous systems of animals, where they are thought to regulate gene expression and synaptic function. Here, we show that neuronal circRNA biosynthesis is mediated by the pan-neuronal RNA-binding protein ELAV. In

Indexed as

Drosophila melanogasterDrosophila ProteinsNeuronsRNAAnimalsBrainELAV ProteinsGene Expression Regulation, DevelopmentalIntronsRNA, CircularRNA SplicingDrosophila ProteinsELAV protein, DrosophilaELAV ProteinsRNARNA, Circularback-splicingcircular RNAsDrosophilaELAVnervous systemreverse complementary matches (RCMs)RNA binding motifRNA-binding proteinsRNA processingsplicing

Identifiers

PMID40490354
PMCPMC12404201

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.