ArticleNature2025
NINJ1 regulates plasma membrane fragility under mechanical strain.
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Mechanotransduction by nuclear envelope tension.Nucleus (Austin, Tex.) · 2026Review
- NINJ1-mediated membrane rupture bridges cell death to tissue inflammation.Biochemical Society transactions · 2026Review
- Metabolic hallmarks of regulated cell death.Cell research · 2026Review
- The gasdermin family: from pyroptosis mechanisms to therapeutic targets.Signal transduction and targeted therapy · 2026Review
- NINJ1: implications for plasma membrane rupture and disease.Biochemical Society transactions · 2026Review
- Bile Acid Glycochenodeoxycholic Acid (GCDCA) Might Induce the Loss of Plasma Membrane Integrity and the Release of LDH From Ovarian Granulosa Cells, With Implications in PCOS.Journal of applied toxicology : JAT · 2026Article
- Ninjurin-1 mediates hepatic ischemia-reperfusion injury.Science advances · 2026Article
- Lipid Bilayer-Confined J-Aggregation Transduces Cell Membrane Mechanics into Photoacoustic Signals.Journal of the American Chemical Society · 2026Article
- Structural and molecular principles of DAMP biology.Nature structural & molecular biology · 2026Review
- Surveying the roles of NINJ1 in plasma membrane rupture.Nature structural & molecular biology · 2026Article
- NINJ1 plays a vital role in the release of neutrophil extracellular traps during acute lung injury.Cell death & disease · 2026Article
- Cell Death by Holocrine Secretion: The Final Step of Epithelial Differentiation in Sebaceous Glands.Cells · 2026Review
- Infection-induced glucose starvation triggers NINJ1-dependent macrophage lysis and Candida escape.Nature communications · 2026Article
- Research Progress on NINJ1-Mediated Plasma Membrane Rupture Regulation of Pathogen Infection Process.International journal of molecular sciences · 2026Review
- Ubc9-mediated SUMOylation of Ninj1 alleviates inflammatory responses in hepatic ischaemia/reperfusion injury.Clinical and translational medicine · 2026Article
- NINJ1 ubiquitination by TRIM72 protects against plasma membrane rupture and AKI-CKD progression.Cell death and differentiation · 2026Article
- A novel PCOS susceptibility gene, cathepsin B, might be likely to contribute to the pyroptosis of ovarian granulosa cells.Journal of assisted reproduction and genetics · 2026Article
- The role of NINJ1 in diseases.Cell death discovery · 2026Review
- Structural basis and regulation of GSDME pore formation.Nature communications · 2026Article
- Amodiaquine Enhances Anti-Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
Corrections and comments
- Erratum issued
- Update of
Authors and funding
25 authors.
Yunfeng Zhu *Department of Critical Care Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.ORCID 0009-0001-4381-7577
Fang Xiao *Department of Critical Care Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Yiling Wang *Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Yufang Wang *Institute of Precision Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Jialin Li *Department of Critical Care Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Dongmei Zhong *Institute of Precision Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.ORCID 0009-0007-0710-0302
Zhilei HuangInstitute of Precision Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Miao YuInstitute of Precision Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Zhirong WangInstitute of Intelligent Manufacturing Technology, Shenzhen Polytechnic University, Shenzhen, China.ORCID 0009-0003-9919-4043
Joshua BarbaraNovartis Biomedical Research, San Diego, CA, USA.ORCID 0009-0000-6735-7061
Christopher PlunkettNovartis Biomedical Research, San Diego, CA, USA.ORCID 0000-0002-6888-9040
Mengxue ZengNational Institute of Biological Sciences, Beijing, China.
Yiyan SongDepartment of Anesthesiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Tian TanDepartment of Anesthesiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Ruibin ZhangInstitute of Precision Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Kezhen XuInstitute of Precision Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Zhongxing WangDepartment of Anesthesiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Changjie CaiDepartment of Critical Care Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Xiangdong GuanDepartment of Critical Care Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Scott HammackNovartis Biomedical Research, San Diego, CA, USA.ORCID 0009-0008-2577-5730
Liang ZhangInstitute of Intelligent Manufacturing Technology, Shenzhen Polytechnic University, Shenzhen, China.
Zheng ShiDepartment of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ, USA. zheng.shi@rutgers.edu.ORCID 0000-0002-5214-1871
Fu-Li XiangInstitute of Precision Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. xiangfli@mail.sysu.edu.cn.ORCID 0009-0006-0666-0538
Feng ShaoNational Institute of Biological Sciences, Beijing, China.ORCID 0000-0002-9562-7791
Jie XuInstitute of Precision Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. xujie56@mail.sysu.edu.cn.ORCID 0000-0003-4049-0991
Funding
Understanding the viscoelasticity, surface tension, and membrane interactions of biomolecular condensates in live cellsR35GM147027 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI Zheng Shi · 2022 to 2026
$1.6MNIGMS NIH HHS R35 GM147027
Abstract
The integrity of the plasma membrane is vital for nearly all aspects of cell functioning
Indexed as
Cell Adhesion Molecules, NeuronalCell MembraneStress, MechanicalAnimalsCell Membrane PermeabilityHumansMicePyroptosisCell Adhesion Molecules, Neuronal
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.