ArticleInternational journal of epidemiology2025
Long-term risk of chronic liver disease after pre-eclampsia.
Article in International journal of epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Observational
- Pre-Eclampsia-Induced Maternal Liver Dysfunction: Systematic Review, Meta-Analysis and Meta-Regression of Observation Studies.Life (Basel, Switzerland) · 2026Review
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7 authors.
Funding
Abstract
backgroundPre-eclampsia is associated with acute hepatic complications, but the risk of developing chronic liver disease is unclear. We determined whether pre-eclampsia was associated with chronic liver disease for up to three decades after pregnancy.
methodsWe conducted a longitudinal population-based cohort study of 1 460 099 pregnant women with and without pre-eclampsia in Quebec, Canada, between 1989 and 2022. The main exposure was pre-eclampsia in any pregnancy. Outcomes included hospitalization for liver disease during 26 275 081 person-years of follow-up after pregnancy. Using Cox regression models adjusted for age, comorbidity, and socio-economic disadvantage, we estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between pre-eclampsia and liver disease.
resultsWomen with pre-eclampsia had a higher incidence of hospitalization for liver disease than women without pre-eclampsia (119.3 vs. 61.5 per 100 000 person-years). During a median follow-up of 18.4 years, pre-eclampsia was associated with 1.85 times the risk of hospitalization for liver disease (95% CI 1.75-1.95). Early-onset pre-eclampsia (HR 2.36, 95% CI 2.04-2.74), superimposed pre-eclampsia (HR 2.78, 95% CI 2.30-3.36), and pre-eclampsia recurring in more than one pregnancy (HR 3.00, 95% CI 2.59-3.46) were strongly associated with liver hospitalization. Associations were present with several liver complications, including hepatic cirrhosis, chronic hepatitis, fatty liver disease, and hepatic failure. Pre-eclampsia was more strongly associated with hepatic hospitalization within 5 years of pregnancy, although risks persisted for up to 33 years later.
conclusionPre-eclampsia is associated with the long-term risk of liver disease up to 33 years after pregnancy.
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