ArticleMedicine2025
Development of a nomogram for predicting positive margins after cold knife conization in patients with high-grade squamous intraepithelial lesions.
Article in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Effect of prophylactic HPV vaccination and timing of administration on recurrence of cervical HSIL after LEEP: A retrospective study.Medicine · 2026Article
- A Competing-Risks Approach to the Progression, Regression and Persistence of High-Grade Cervical Dysplasia in Patients over 30 Years Old-A Prospective Study.Journal of clinical medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The objective was to develop a nomogram for predicting positive margins after cold knife conization (CKC) in patients with high-grade squamous intraepithelial lesion (HSIL). This retrospective study included patients who underwent CKC at Baoding No. 1 Central Hospital between December 2013 and March 2024. Patients were divided into training (between December 2013 and December 2022) and validation (between January 2023 and March 2024) sets. The least absolute shrinkage and selection operator regression was applied to filter and select relevant variables. Multivariable logistic regression was used for nomogram construction. The model performance was evaluated using various methods, including receiver operating characteristics, decision curve analysis, and calibration analysis. The training and validation sets included 985 and 227 patients, respectively. Age (OR = 1.046, 95% CI: 1.028-1.064, P < .001), cervical intraepithelial neoplasia quadrants by punch biopsy (OR = 1.561, 95% CI: 1.348-1.808, P < .001), HSIL type (OR = 1.711, 95% CI: 1.102-2.657, P = .017), and gland involvement (OR = 1.552, 95% CI: 1.073-2.247, P = .020) were associated with positive margins and used for nomogram construction. The predictive model yielded area under the curves of 0.744 and 0.754 in the training and validation sets, respectively. Decision curve analysis indicated a net benefit when using the nomogram, and the calibration curves demonstrated a good fit. This study constructed a nomogram model for predicting positive margins after CKC in patients with HSIL. This nomogram may enable early and accurate patient evaluation, potentially improving clinical outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.