Evidence map›Paper›PMID 40489839›Full record

Observational studyMedicine2025

Incidence of catheter-related infection in cancer patients receiving parenteral nutrition: A retrospective cohort study of French administrative claims data.

Julien Taieb, Olivier Pellerin, Gérard de Pouvourville, Jacques Massol, Séverine Jaskulski, Julian Shepelev, Laurène Gautier, Patricia Medina

Abstract readObservational Study
In one paragraph

Observational study in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Julien TaiebGastrointestinal Oncology Department, Hôpital Européen Georges Pompidou, AP-HP, Université Paris-Cité, SIRIC CARPEM, Paris, France.ORCID 0000-0002-9955-4753
Olivier PellerinAssistance Publique Hôpitaux de Paris, Service de Radiologie Interventionnelle Vasculaire et Oncologique, Hôpital Européen Georges Pompidou, AP-HP, Université de Paris, Paris, France.
Gérard de PouvourvilleDépartement d'Economie, ESSEC Business School, Cergy-Pontoise, France.
Jacques MassolChief Medical Officer at Aixial Group, Clinical Research Organisation, France.
Séverine JaskulskiMedical Affairs, Responsable Médical et Scientifique/Affaires Médicales, Nutrition clinique & Pharmaceuticals, Laboratoire Baxter, Guyancourt, France.
Julian ShepelevHealth Economics and Outcomes Research, Baxter Healthcare, Zurich, Switzerland.ORCID 0000-0002-3761-3455
Laurène GautierCerner Enviza (now Oracle Life Sciences), Paris, France.ORCID 0009-0002-0373-2197
Patricia MedinaOracle Life Sciences, Paris, France.

Funding

Baxter Healthcare SA, Switzerland
6 · The paper itself

Abstract

Data confirming parenteral nutrition (PN) as an independent risk factor for catheter-related infection (CRI) are scarce and not recent. This study aims to estimate the effect of PN on CRI in cancer patients after catheter placement. A retrospective cohort analysis of the French National Health Data System was conducted. A total of 5300 gastric, 5975 pancreatic, and 15,102 lung cancer patients with central venous catheter insertion between 2012 and 2016 were included. Potential confounders for CRI were evaluated using Poisson regression. Incidence rates (IRs) of CRI were calculated. Incidence rate ratio (IRR) was estimated to assess the effect of exposure to PN on infection occurrence in all patients and among patients receiving chemotherapy (CT). The independent risk factors found to be associated with CRI were age, sex, Charlson Comorbidity Index, PN, CT, metastasis, and history of infection. After adjustment, there was an increased risk of CRI in patients with versus without PN in gastric (IRR: 1.1165; 95% confidence interval [95% CI]: 1.0119-1.2319), pancreatic (IRR: 1.2071; 95% CI: 1.0985-1.3265), and lung cancer (IRR: 1.1850; 95% CI: 1.0832-1.2962). In patients who received PN, IRs of CRI were higher than in those who did not, for gastric (34.84% vs 29.69%, respectively; P = .0001), pancreatic (38.89% vs 28.58%, respectively; P < .0001), and lung (23.64% vs 22.13%, respectively; P = .0967) cancer cohorts. The results of this National administrative claims database analysis suggested that PN might be one of the independent risk factors for CRI. However, the risk was smaller than previously reported, regardless of whether the patient was receiving CT or not.

Indexed as

Catheterization, Central VenousCatheter-Related InfectionsNeoplasmsParenteral NutritionAdultAgedFemaleFranceHumansIncidenceLung NeoplasmsMaleMiddle AgedPancreatic NeoplasmsRetrospective StudiesRisk Factorscancercatheter-related infectionchemotherapyparenteral nutrition

Identifiers

PMID40489839
PMCPMC12150976

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.