ArticleMedicine2025
Exploration of PDHA1-related prognostic genes in liver fibrosis.
Article in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Mitochondrial PDHA1 acetylation orchestrates lactate-dependent epigenetic reprogramming to promote fibrosis via NUAK2.Cellular and molecular life sciences : CMLS · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Liver fibrosis is characterized by an abnormal accumulation of extracellular matrix proteins, leading to impaired liver function. The pyruvate dehydrogenase alpha 1 (PDHA1) gene, encoding the E1 alpha subunit of the pyruvate dehydrogenase complex, has demonstrated reduced expression in pulmonary fibrosis, suggesting a protective role in fibrotic diseases. This study aimed to identify PDHA1-related gene signatures and explore potential targets for liver fibrosis treatment. Datasets GSE15654 and GSE84044 were sourced from the gene expression omnibus database. Prognostic genes were identified through Pearson correlation analysis, LASSO, and Cox regression in the discovery dataset (GSE15654) and validated using the verification dataset (GSE84044). A prognostic model was constructed and validated with quantitative reverse transcriptase-PCR analysis on surgical resection samples. High PDHA1 expression correlated with improved prognosis in liver fibrosis. Four PDHA1-related prognostic genes (ALDH9A1, ARG1, APOH, and FABP1) were identified as protective factors. Our model accurately predicted patient prognosis, and initial validation with clinical samples supported these conclusions. The prognostic model based on PDHA1-related genes (ALDH9A1, ARG1, APOH, and FABP1) effectively predicts liver fibrosis progression and prognosis. This research provides a novel approach for liver fibrosis prediction and potential treatment strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.