SynthesisMedicine2025
Rapid health technology assessment of galantamine for the treatment of Alzheimer's disease: A review.
Synthesis in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Preformulation Study of Controlled-Release Galantamine Matrix Tablets Containing Polyethylene Oxide, Hydroxypropyl Methylcellulose, and Ethylcellulose.Pharmaceutics · 2025Article
- Stem cell and CRISPR/Cas9 gene editing technology in Alzheimer's disease therapy: from basic research to clinical innovation.Frontiers in genome editing · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
This study evaluates the efficacy, safety, and economics of galantamine in the treatment of Alzheimer disease (AD) patients, and to provide evidence-based reference for optimizing drug selection, dosing strategies, and reimbursement policies in clinical practice. We used galantamine, systematic review, cost, and their synonym as keywords. The PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Weipu, Wanfang database, and Health Technology Assessment organization websites were searched to retrieve studies regarding galantamine for the treatment of AD from database creation to September 20, 2023. We extracted information and pooled the results of the studies for qualitative analyses instead of quantitative meta-analysis. This study incorporated 39 reports. Regarding effectiveness, galantamine significantly improved cognitive function, living capacity, mental behavior, and global functioning of the AD patients compared with the placebo. However, based on available data, it was not possible to infer whether galantamine was more effective than the other acetylcholinesterase inhibitor drugs. AD patients treated with galantamine showed a higher incidence of adverse gastrointestinal effects compared to those treated with placebo. Galantamine showed a higher incidence of adverse gastrointestinal effects than donepezil but a lower rate than rivastigmine. Regarding economics, compared with the placebo and non-pharmacological treatments, galantamine prolonged the duration of full-time care and in some cases even reduced the overall cost of galantamine use. Galantamine showed good efficacy, cost-effectiveness, and mild adverse effects in the treatment of patients with AD by prolonging the duration of full-time care and saving the cost compared with the placebo and non-pharmacological.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.