Evidence map›Paper›PMID 40489800›Full record

ArticleSexually transmitted diseases2025

Optimizing HIV Partner Services for Gay, Bisexual, and Other Men Who Have Sex With Men Previously Diagnosed With HIV: A Modeling Study.

Udodirim N Onwubiko, Adrien Le Guillou, Cynthia Lyles, Kevin M Maloney, Kevin P Delaney, Samuel M Jenness

Abstract read
In one paragraph

Article in Sexually transmitted diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Udodirim N OnwubikoFrom the Department of Epidemiology, Emory University.ORCID 0000-0001-8223-5716
Adrien Le GuillouFrom the Department of Epidemiology, Emory University.
Cynthia LylesDivision of HIV Prevention, Centers for Disease Control and Prevention.
Kevin M MaloneySchool of Public Health, Georgia State University, Atlanta, GA.
Kevin P DelaneyDivision of HIV Prevention, Centers for Disease Control and Prevention.
Samuel M JennessFrom the Department of Epidemiology, Emory University.

Funding

STI Response and Recommendations Under PrEP (STIRRUP)R01MH128130 · NIMH · EMORY UNIVERSITY · PI Samuel Jenness · 2022 to 2026
$3.1M
EpiModel 2.0: Integrated Network Models for HIV/STI Prevention ScienceR01AI138783 · NIAID · EMORY UNIVERSITY · PI JENNESS, SAMUEL · 2018 to 2021
$3.0M
Modeling Antiretroviral-Based Prevention among MSM in the USR21MH112449 · NIMH · EMORY UNIVERSITY · PI JENNESS, SAMUEL · 2017 to 2018
$442k
NCHHSTP CDC HHS NU38PS004650NIAID NIH HHS R01 AI138783NIMH NIH HHS R01 MH128130NIMH NIH HHS R21 MH112449
6 · The paper itself

Abstract

backgroundHIV Partner Services (HIV-PS) is a vital strategy for identifying and linking individuals to treatment and prevention; however, its population-level impact has been limited. This study investigated the potential impact of expanding HIV-PS to include previously diagnosed individuals and a broader sexual partner network in reducing HIV incidence among gay, bisexual, and other men who have sex with men (GBMSM).

methodsStochastic network models were used to simulate HIV and bacterial sexually transmitted infection transmission within male same-sex partnerships in Atlanta. Two primary interventions were examined: prioritizing people with previously diagnosed HIV who were out-of-care (PWDH-OOC) in routine HIV-PS and expanding partner elicitation to include partners of HIV-positive partners of index cases. We quantified how modifications to HIV-PS cascade steps under these interventions would impact HIV incidence among GBMSM.

resultsExpanded partner elicitation modestly increased the pool of partners eligible for linkage to transmission-disrupting services, with minimal impact on HIV incidence. In contrast, including PWDH-OOC led to a 10-fold increase in both index-case and partner pools. However, substantial reductions in HIV incidence required enhancements to other HIV-PS steps, particularly in partner identification and antiretroviral therapy (ART) reengagement for PWDH-OOC. Prioritizing ART reengagement for PWDH-OOC, alongside optimized HIV-PS, resulted in up to 63% of HIV infections being averted.

conclusionsOur study highlights the potential of strategic improvements to HIV-PS for accelerating HIV incidence reduction among GBMSM. Synergistic optimization of HIV-PS, along with prioritizing ART reengagement for previously diagnosed individuals, will be essential for achieving substantial reductions in HIV incidence.

Indexed as

Contact TracingHIV InfectionsHomosexuality, MaleSexual and Gender MinoritiesSexual PartnersAdultBisexualityGeorgiaHumansIncidenceMale

Identifiers

PMID40489800
PMCPMC12233171

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.