ArticleAnalytical chemistry2025
Top-Down Characterization of Yeast tRNA by Gas-Phase Fractionation and Collisionally Activated Dissociation Informed by Electron Photodetachment Charge Reduction Mass Spectrometry.
Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Activation of Oligonucleotide Polyanions Using Collisions, Electrons and Photons in a timsOmni Platform.Journal of the American Society for Mass Spectrometry · 2026Article
- Proton transfer reagent cations for ion-ion charge state manipulation of high mass negatively-charged analytes in an electrodynamic ion trap.The Analyst · 2026Article
- Progress in Tandem Mass Spectrometry Data Analysis for Nucleic Acids.Mass spectrometry reviewsReview
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Authors and funding
4 authors.
Funding
Abstract
Many transfer RNAs (tRNAs) are heavily modified and exhibit high sequence heterogeneity, making them challenging targets for characterization. Tandem mass spectrometry can interrogate multiple covalent modifications present on a single type of tRNA at the nucleotide level simultaneously. To expand the capacity of MS-based methods to determine co-occurring modifications, top-down methodologies that examine intact RNAs offer a compelling strategy. Here we report a gas-phase fractionation MS/MS method in which narrow segments of a mass spectrum are isolated and subjected to either ultraviolet (UV) photoactivation or collisionally activated dissociation (CAD). UV photoactivation causes charge reduction via electron photodetachment, dispersing the precursor ions over a broader
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