Evidence map›Paper›PMID 40489785›Full record

ArticleBiochemistry2025

Development of Mutant M

Jaroslawna Meister, Lizzy Wanka, Nicole A Perry-Hauser, Liu Liu, Tina M Iverson, Vsevolod V Gurevich, Annette G Beck-Sickinger, Andrew C Kruse, Jürgen Wess

Abstract read
In one paragraph

Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jaroslawna MeisterMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, United States.
Lizzy WankaInstitute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig 04109, Germany.
Nicole A Perry-HauserDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.
Liu LiuMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, United States.
Tina M IversonDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.ORCID 0000-0001-8816-6352
Vsevolod V GurevichDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.ORCID 0000-0002-3950-5351
Annette G Beck-SickingerInstitute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig 04109, Germany.ORCID 0000-0003-4560-8020
Andrew C KruseDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, United States.ORCID 0000-0002-1467-1222
Jürgen WessMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, United States.ORCID 0000-0003-0818-1232

Funding

Molecular basis for arrestin-mediated signalingR01GM120569 · NIGMS · VANDERBILT UNIVERSITY · PI T M Iverson · 2016 to 2026
$1.9M
Molecular basis of G protein-coupled receptor functionZ01DK031129 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI WESS, JURGEN · 2007 to 2008
$832k
Intramural NIH HHS Z01 DK031129NIGMS NIH HHS R01 GM120569
6 · The paper itself

Abstract

The M

Indexed as

beta-ArrestinsGTP-Binding ProteinsReceptor, Muscarinic M3AnimalsCHO CellsCricetulusHEK293 CellsHumansMiceMutationSignal Transductionbeta-ArrestinsGTP-Binding ProteinsReceptor, Muscarinic M3

Identifiers

PMID40489785
PMCPMC13005129

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.