ArticleRheumatology (Oxford, England)2025
Sleep and circadian parameters in Behçet's syndrome: a comparative analysis using actigraphy and questionnaires.
Article in Rheumatology (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Medication adherence in Behçet's syndrome: real-world data from a tertiary referral cohort.RMD open · 2026Article
- Exploring sleep health and circadian rhythm disruption in Sjögren's disease: an accelerometric and self-reported cross-sectional study.Rheumatology (Oxford, England) · 2026Article
- Rethinking Pain Assessment: Subjective Scales, Biomarkers, and Multimodal Integration.Journal of pain research · 2026Review
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Authors and funding
12 authors.
Funding
Abstract
objectiveSleep disturbances are highly prevalent in Behçet syndrome (BS) patients. Within this population, sleep disturbances are frequently associated with active disease and comorbid fibromyalgia. However, possible sleep impairments in BS patients without these conditions remain poorly explored, along with BS patients' obstructive sleep apnoea syndrome (OSAS) risk and circadian rhythm preferences. We aimed to address these research gaps through a cross-sectional study comparing sleep and circadian parameters between BS patients, with or without active disease and comorbid fibromyalgia, and healthy controls (HCs).
methodsParticipants' sleep and circadian parameters were evaluated objectively via actigraphy and subjectively through the Pittsburgh Sleep Quality Index and the reduced Morningness-Eveningness Questionnaire. A comprehensive clinical evaluation investigated sociodemographic data, disease activity and comorbid fibromyalgia. Possible predictors of sleep and circadian parameters were tested estimating linear regression models.
resultsForty-five BS patients and 61 age-, BMI-, sex- and smoking habits-matched HCs were enrolled. Only BS patients with active disease and/or fibromyalgia showed significantly lower sleep quality, significantly higher sleep fragmentation and a tendence towards less robust circadian rhythms compared to other participants. Instead, BS patients without those conditions did not significantly differ from HCs in sleep and circadian parameters. Furthermore, a higher actigraphically-determined OSAS risk was found in all BS patients compared to HCs.
conclusionsActive disease and fibromyalgia are associated with sleep and circadian rhythm disturbances in BS patients. Screening for sleep and circadian rhythm disturbances may be advised in BS patients with these conditions, while OSAS screening may be recommended in all BS patients with sleep disturbances.
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