ArticleProceedings of the National Academy of Sciences of the United States of America2025
A specific negatively charged sequence confers intramolecular regulation on Munc13-1 function in synaptic exocytosis.
Kexu Zhao, Li Zhang, Mengshi Lei, Ziqi Jin, Tianxin Du, Hong Zhang, Yin Sheng, Zhitao Hu, Shen Wang, Cong Ma
Abstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Kexu ZhaoKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Li ZhangKey Clinical Laboratory of Henan Province, Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Mengshi LeiKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Ziqi JinKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Tianxin DuKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Hong ZhangKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Yin ShengSchool of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan 430074, China.
Shen WangKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.ORCID 0000-0002-5013-1039 Cong MaKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.ORCID 0000-0002-7814-0500 Funding
Hubei Provincial Natural Science Foundation of China 2024AFA005Interdisciplinary Research Programme of HUST 2023JCYJ006Interdisciplinary Research Programme of HUST 2024JCYJ011MOST | National Natural Science Foundation of China (NSFC) 32225024MOST | National Natural Science Foundation of China (NSFC) 32401035MOST | National Natural Science Foundation of China (NSFC) 32421003MOST | National Natural Science Foundation of China (NSFC) 92254302National Science and Technology Major Project () 2021ZD0202501
6 · The paper itselfAbstract
Munc13 family proteins are crucial for the secretion of neurotransmitters and hormones necessary for cell communication. They share a conserved C-terminal region that includes C
Indexed as
ExocytosisNerve Tissue ProteinsSynapsesAmino Acid SequenceAnimalsCalciumHumansMiceProtein BindingProtein DomainsRatsSNARE ProteinsCalciumNerve Tissue ProteinsSNARE ProteinsUnc13a protein, ratautoinhibitioncalciumMunc13neurotransmitter releaseSNARE
Identifiers
PMID40489622
PMCPMC12184661
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