Evidence map›Paper›PMID 40489619›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Protein kinase A signaling regulates immune evasion by shaving and concealing fungal β-1,3-glucan.

Arnab Pradhan, Olga A Nev, Ian Leaves, Oleg A Nev, Qinxi Ma, Gillian Milne, Grace Patterson, Mihai G Netea, Lars P Erwig, Rhys A Farrer and 4 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. A Synthetic β-Mannan Epitope Enables Immunization and Detection of Candida auris.Angewandte Chemie (International ed. in English) · 2026
    Article
  2. Review
  3. Article
  4. Glycan microarray analysis ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Arnab Pradhan *Medical Research Council Centre for Medical Mycology at the University of Exeter, Department of Biosciences, Faculty of Health and Life Sciences, Exeter EX4 4QD, United Kingdom.ORCID 0000-0003-4328-3912
Olga A Nev *Medical Research Council Centre for Medical Mycology at the University of Exeter, Department of Biosciences, Faculty of Health and Life Sciences, Exeter EX4 4QD, United Kingdom.ORCID 0000-0003-0055-2211
Ian LeavesMedical Research Council Centre for Medical Mycology at the University of Exeter, Department of Biosciences, Faculty of Health and Life Sciences, Exeter EX4 4QD, United Kingdom.
Oleg A NevSoftware Consultant, Belgrade, Serbia.
Qinxi MaMedical Research Council Centre for Medical Mycology at the University of Exeter, Department of Biosciences, Faculty of Health and Life Sciences, Exeter EX4 4QD, United Kingdom.
Gillian MilneMicroscopy and Histology Facility, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom.
Grace PattersonBioimaging Centre, Department of Biosciences, University of Exeter, Exeter EX4 4QD, United Kingdom.ORCID 0009-0000-1900-0308
Mihai G NeteaDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen 6525 GA, The Netherlands.
Lars P ErwigCancer Research UK, London E20 1JQ, United Kingdom.
Rhys A FarrerMedical Research Council Centre for Medical Mycology at the University of Exeter, Department of Biosciences, Faculty of Health and Life Sciences, Exeter EX4 4QD, United Kingdom.ORCID 0000-0001-8456-7458
Gordon D BrownMedical Research Council Centre for Medical Mycology at the University of Exeter, Department of Biosciences, Faculty of Health and Life Sciences, Exeter EX4 4QD, United Kingdom.
Hugo A van den BergMathematics Institute, University of Warwick, Coventry CV4 7AL, United Kingdom.ORCID 0000-0002-8230-6227
Neil A R GowMedical Research Council Centre for Medical Mycology at the University of Exeter, Department of Biosciences, Faculty of Health and Life Sciences, Exeter EX4 4QD, United Kingdom.ORCID 0000-0002-2776-5850
Alistair J P BrownMedical Research Council Centre for Medical Mycology at the University of Exeter, Department of Biosciences, Faculty of Health and Life Sciences, Exeter EX4 4QD, United Kingdom.ORCID 0000-0003-1406-4251

Funding

EC | European Research Council (ERC) 833247Netherlands Organization for Scientific Research Spinoza grantNIHR | NIHR Exeter Clinical Research Facility (NIHR Exeter CRF) NIHR203320UKRI | Medical Research Council (MRC) MR/M026663/2UKRI | Medical Research Council (MRC) MR/V006169/1UKRI | MRC | Medical Research Council Centre for Medical Mycology (MRC CMM) MR/N006364/2 MR/V033417/1Wellcome TrustWellcome Trust (WT) 101873 200208 217163/Z/19/ZWellcome Trust (WT) 224323/Z/21/ZWellcome Trust (WT) 225303/Z/22/Z
6 · The paper itself

Abstract

Fungal pathogens infect billions and kill millions of people each year. Many of these pathogens have evolved strategies to evade our antifungal immune defenses.

Indexed as

beta-GlucansCandida albicansImmune EvasionSignal TransductionCell WallHumansbeta-1,3-glucanbeta-GlucansCandida albicansmathematical modelingpathogen-associated molecular patternsβ-glucan masking dynamics

Identifiers

PMID40489619
PMCPMC12184398

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.