Evidence map›Paper›PMID 40489607›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

The CARD14

Lucrezia Zerillo, Tiziana Zotti, Angelapia Tutela, Jessica Raffaella Madera, Gabriella Grasso, Pasquale Vito, Romania Stilo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lucrezia Zerillo *Genus Biotech, Unit of Molecular Biology and Genetics, Benevento 82100, Italy.ORCID 0000-0002-5935-7077
Tiziana Zotti *Department of Sciences and Technologies, University of Sannio, Benevento 82100, Italy.ORCID 0000-0003-4753-116X
Angelapia TutelaDepartment of Sciences and Technologies, University of Sannio, Benevento 82100, Italy.
Jessica Raffaella MaderaDepartment of Sciences and Technologies, University of Sannio, Benevento 82100, Italy.
Gabriella GrassoDepartment of Sciences and Technologies, University of Sannio, Benevento 82100, Italy.
Pasquale VitoGenus Biotech, Unit of Molecular Biology and Genetics, Benevento 82100, Italy.
Romania StiloDepartment of Sciences and Technologies, University of Sannio, Benevento 82100, Italy.

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca (MIUR) F53D23012270001
6 · The paper itself

Abstract

The Mitochondrial Antiviral Signaling Protein (MAVS) is a key adaptor in antiviral immunity, mediating type I interferon responses downstream of RIG1 and TLR3. While MAVS regulation is essential for antiviral defense, its modulation in keratinocytes is poorly understood. Here, we examine the role of the CARD14-BCL10-MALT1 (CBM) complex, a skin-specific signaling module, in controlling MAVS-dependent antiviral responses. We identify CARD14

Indexed as

Adaptor Proteins, Signal TransducingB-Cell CLL-Lymphoma 10 ProteinCARD Signaling Adaptor ProteinsGuanylate CyclaseKeratinocytesMembrane ProteinsMucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 ProteinNeoplasm ProteinsHEK293 CellsHumansImmunity, InnateInterferon Regulatory Factor-3Interferon Type INF-kappa BPoly I-CPsoriasisAdaptor Proteins, Signal TransducingB-Cell CLL-Lymphoma 10 ProteinBCL10 protein, humanCARD14 protein, humanCARD Signaling Adaptor ProteinsGuanylate CyclaseInterferon Regulatory Factor-3Interferon Type IIRF3 protein, humanMALT1 protein, humanMAVS protein, humanMembrane ProteinsMucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 ProteinNeoplasm ProteinsNF-kappa BPoly I-Cantiviral responseinnate immunitypsoriasisskin homeostasis

Identifiers

PMID40489607
PMCPMC12184436

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.