Evidence map›Paper›PMID 40489544›Full record

ArticleCirculation2025

Loss of Methyltransferase and Hypomethylated m6A Sarcomere Transcripts Leading to Early-Onset Dilated Cardiomyopathy.

Sophie Marie Hand, Yi Zhao, Donna Li, Savanna Burke, Hee-Woong Lim, Jessie Yester, Vidu Garg, Federica Accornero, Xiao Li, Deqiang Li and 1 more

Abstract readLetter
In one paragraph

Article in Circulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. mExperimental & molecular medicine · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sophie Marie HandCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH (S.M.H., D.L., S.B., J.Y., V.G., D.L., J.J.).
Yi ZhaoGene Editing Laboratory, Texas Heart Institute at Baylor College of Medicine, Houston (Y.Z., X.L.).ORCID 0000-0003-0989-8825
Donna LiCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH (S.M.H., D.L., S.B., J.Y., V.G., D.L., J.J.).ORCID 0009-0002-8662-4588
Savanna BurkeCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH (S.M.H., D.L., S.B., J.Y., V.G., D.L., J.J.).
Hee-Woong LimDivision of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, OH (H.-W.L.).ORCID 0000-0001-8599-1808
Jessie YesterCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH (S.M.H., D.L., S.B., J.Y., V.G., D.L., J.J.).ORCID 0000-0003-2242-1634
Vidu GargCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH (S.M.H., D.L., S.B., J.Y., V.G., D.L., J.J.).ORCID 0000-0002-3778-5927
Federica AccorneroDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI (F.A.).ORCID 0000-0003-1209-7228
Xiao LiGene Editing Laboratory, Texas Heart Institute at Baylor College of Medicine, Houston (Y.Z., X.L.).ORCID 0000-0001-8527-4438
Deqiang LiCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH (S.M.H., D.L., S.B., J.Y., V.G., D.L., J.J.).ORCID 0000-0002-4603-2855
Jihyun JangCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH (S.M.H., D.L., S.B., J.Y., V.G., D.L., J.J.).ORCID 0000-0002-4548-2037

Funding

Post-transcriptional regulation of cardiac hypertrophyR01HL136951 · NHLBI · OHIO STATE UNIVERSITY · PI Federica Accornero · 2017 to 2026
$4.7M
Genetic dissection of Cardiac Conduction System homeostasis and RepairR01HL142704 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Jun Wang · 2020 to 2026
$3.0M
Mechanistic characterization of a new master regulator of cardiac virus infectionsR01HL154001 · NHLBI · OHIO STATE UNIVERSITY · PI ACCORNERO, FEDERICA, YOUNT, JACOB · 2020 to 2023
$2.3M
METTL3 in regulation of the aging processR01AG079842 · NIA · OHIO STATE UNIVERSITY · PI Federica Accornero · 2023 to 2026
$2.1M
Cardiac regeneration by histone deacetylasesR01HL153406 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI LI, DEQIANG · 2020 to 2024
$1.9M
Role of cardiac m6A methyltransferasesR01HL176685 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI Jihyun Jang · 2025 to 2026
$1.4M
Senescent Cell States in Single Ventricle Disease with Heart FailureR01HL177644 · NHLBI · TEXAS HEART INSTITUTE · PI James F Martin · 2025 to 2026
$1.3M
American Heart Association-American Stroke Association 23CDA1046244American Heart Association-American Stroke Association 23IPA1048560NHLBI NIH HHS R01 HL136951NHLBI NIH HHS R01 HL142704NHLBI NIH HHS R01 HL153406NHLBI NIH HHS R01 HL154001NHLBI NIH HHS R01 HL176685NHLBI NIH HHS R01 HL177644NIA NIH HHS R01 AG079842
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

dilated cardiomyopathyheart developmentm6A methyltransferaseRNA metabolismsarcomere

Identifiers

PMID40489544
PMCPMC12158418

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.