Evidence map›Paper›PMID 40489290›Full record

SynthesisJournal of periodontology2025

The influence of prosthetic designs on peri-implant bone loss: An AO/AAP systematic review and meta-analysis.

Guo-Hao Lin, Eric Lee, Shayan Barootchi, Paul S Rosen, Donald Curtis, Joseph Kan, Hom-Lay Wang

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Journal of periodontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Influence of Concave Versus Convex Emergence Profiles on Midfacial Mucosal Stability-A Systematic Review With Meta-Analysis.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026
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  4. Under pressure: Unraveling the impact of occlusal overload on peri-implant health-A systematic review.Journal of prosthodontics : official journal of the American College of Prosthodontists · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Guo-Hao LinDepartment of Orofacial Sciences, University of California San Francisco School of Dentistry, San Francisco, California, USA.ORCID https://orcid.org/0000-0003-1290-9994
Eric LeeDepartment of Orofacial Sciences, University of California San Francisco School of Dentistry, San Francisco, California, USA.
Shayan BarootchiDepartment of Oral Medicine, Infection, and Immunity, Harvard University School of Dental Medicine, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-5347-6577
Paul S RosenDepartment of Periodontics, Rutgers University School of Dental Medicine, Newark, New Jersey, USA.
Donald CurtisDepartment of Preventive and Restorative Dental Sciences, University of California San Francisco School of Dentistry, San Francisco, California, USA.
Joseph KanDepartment of Implant Dentistry, School of Dentistry, Loma Linda University, Loma Linda, California, USA.
Hom-Lay WangDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0003-4238-1799

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImplant prosthetic design significantly impacts peri-implant health. This systematic review and meta-analysis explored emerging concepts in prosthetic considerations, appraising the level of evidence and clinical significance of these suprastructures on peri-implant marginal bone loss (MBL).

methodsAn electronic search of three databases and a manual search of peer-reviewed journals for relevant articles published in English between January 1980 and December 2023 were performed. Eligible studies featured dental implants restored within ≥12 months, with ≥10 implants in each group. Inverse variance meta-analyses were performed to compare various prosthetic factors and their impact on MBL and the risk of peri-implantitis.

resultsScrew-retained versus cement-retained prostheses demonstrated no significant difference in MBL (six articles, p = 0.51). Nonsplinted implants exhibited lower MBL compared to their splinted counterparts (eight articles, p = 0.04). Platform-switched abutments were correlated with reduced MBL compared to platform-matched ones (20 articles, p < 0.0001). Internal connections, particularly conical ones, displayed less MBL than external connections (20 articles, p < 0.0001). The crown-to-implant ratio did not significantly affect MBL (five articles, p = 0.32). Abutment heights ≥2 mm are associated with less MBL than heights <2 mm (12 articles, p < 0.0001). Implementing a one abutment-one time protocol resulted in less MBL than repeated abutment disconnections (10 articles, p < 0.0001). Emergence angles <30° and a concave/straight profile led to lower peri-implantitis risk (two articles each; p = 0.05 and p = 0.03, respectively).

conclusionsNonsplinted implants, platform-switched abutments, abutment heights ≥2 mm, and a one abutment-one time approach yielded significant reductions in MBL compared to their counterparts. Furthermore, emergence angles <30° and a concave/straight emergence profile were linked to decreased peri-implantitis risk. Meanwhile, factors such as screw-retained versus cement-retained prostheses and crown-to-implant ratio yielded no significant difference in MBL. PLAIN LANGUAGE SUMMARY: The design of implant-supported tooth replicas plays a key role in keeping the surrounding gums and bone healthy. This study reviewed research from 1980 to 2023 to examine how different design features of these restorations impact oral tissue health. A total of 93 studies were included, focusing on patients aged 18 years and older, with at least 10 patients in each group. The findings showed that individual tooth replicas (rather than splinted ones) led to better gum health. A horizontal offset at the implant-replica junction helped reduce bone loss. Implants with internal connections (inside the implant body) performed better than those with external connections. Tooth replicas with narrow contours at the implant junction were more beneficial than convex shapes. Additionally, using abutments taller than 2 mm and minimizing the number of times an abutment is removed during fabrication helped preserve surrounding tissues. These findings highlight how careful implant design can improve long-term oral health, reducing complications and maintaining stability around dental implants.

Indexed as

Alveolar Bone LossDental ImplantsDental Prosthesis DesignDental Prosthesis, Implant-SupportedHumansPeri-ImplantitisDental Implantsbone–implant interfacedental implantsimplant‐supported dental prosthesismeta‐analysisperi‐implantitissystematic review

Identifiers

PMID40489290
PMCPMC12273757

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.