Evidence map›Paper›PMID 40489161›Full record

Trial reportExperimental and clinical psychopharmacology2025

The effect of "ice" components in sweet-flavored nicotine-containing e-liquids among young adult e-cigarette users.

Wei Li, Danielle R Davis, Ran Wu, Ralitza Gueorguieva, Barry G Green, Suchitra Krishnan-Sarin

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Experimental and clinical psychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wei LiDepartment of Psychiatry, Yale School of Medicine, Yale University.ORCID 0000-0001-7530-3485
Danielle R DavisDepartment of Psychiatry, Yale School of Medicine, Yale University.
Ran WuDepartment of Psychiatry, Yale School of Medicine, Yale University.
Ralitza GueorguievaDepartment of Biostatistics, Yale School of Public Health, Yale University.
Barry G GreenJohn B. Pierce Laboratory, Yale School of Medicine, Yale University.
Suchitra Krishnan-SarinDepartment of Psychiatry, Yale School of Medicine, Yale University.

Funding

Yale Center for the Study of Tobacco Product Use and Addiction (YCSTP) Project 2: Addictive Threshold of Nicotine and the Impact of SweetenersU54DA036151 · NIDA · YALE UNIVERSITY · PI LISA M FUCITO · 2018 to 2026
$41.6M
Food and Drug Administration; Center for Tobacco ProductsNational Institutes of Health; National Institute on Drug AbuseNIDA NIH HHS U54 DA036151
6 · The paper itself

Abstract

E-cigarette use is prevalent among young adults, with "ice" e-cigarettes/liquids that combine sweet and cooling flavors becoming increasingly popular. This study examines if an "ice" component (e.g., menthol) alters liking, sensory experiences, and reward of sweet-flavored nicotine e-liquids among young adults. A double-blinded laboratory session was conducted with past-month e-cigarette users aged 18-20 (N = 40). Participants were exposed in random order to a sweet-flavored (watermelon) e-liquid with and without menthol in two 10-puff bouts. Both e-liquids contained 36 mg/ml nicotine salt and 50:50 propylene glycol/vegetable glycerin. Participants rated flavor liking and overall vaping experience using the Labeled Hedonic Scale, sensory effects using generalized Labeled Magnitude Scales, and reward effects using the Drug Effects Questionnaire. Linear mixed models analyzed outcomes with flavor condition, sex, and their interaction as fixed effects, adjusting for flavor order. Participants (average age = 19.1 years,

Indexed as

Electronic Nicotine Delivery SystemsFlavoring AgentsMentholNicotineVapingAdolescentDouble-Blind MethodFemaleHumansMaleRewardSweetening AgentsTasteYoung AdultFlavoring AgentsMentholNicotineSweetening Agents

Identifiers

PMID40489161
PMCPMC12817302

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.