ArticleBehavioral neuroscience
Deep brain stimulation of nucleus basalis of meynert: Effect of stimulation mode and duration on learning in rat model of dementia.
Article in Behavioral neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Novel neurotherapeutic targets for substance use disorders: Neuroplasticity, neuroinflammation, gasotransmitters and non-canonical organ systems.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Deep brain stimulation of nucleus basalis of meynert: Effect of stimulation mode and duration on learning in rat model of dementia.Behavioral neuroscienceArticle
Corrections and comments
- Update of
Authors and funding
11 authors.
Funding
Abstract
Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has been preliminarily investigated as a potential treatment for dementia. The degeneration of NBM cholinergic neurons is a pathological feature of many forms of dementia. Although NBM stimulation has been demonstrated to improve learning, the ideal parameters for NBM stimulation have not been elucidated. This study assesses the differential effects of varying stimulation patterns and duration on learning in a dementia rat model with cholinergic deficits. 192-IgG saporin (SAP) or Dulbecco's phosphate buffered saline was injected into the NBM to produce dementia in rats. Next, all rats underwent unilateral implantation of a DBS electrode in the NBM. The experimental groups consisted of (a) normal, (b) untreated SAP-injected rats with cholinergic deficits, and (c) SAP rats receiving NBM DBS. The stimulation paradigms included testing different modes (tonic and burst) and durations (1 hr, 5 hr, and 24 hr/day) over 10 daily sessions. Memory was assessed using two established learning paradigms: novel object recognition and auditory operant chamber learning. Both normal and stimulated rats demonstrated improved performance in novel object recognition and auditory learning as compared to the unstimulated SAP group. The burst stimulation groups performed better than the tonic group. Increasing the daily stimulation duration to 24 hr did not further improve cognitive performance in an auditory recognition task and degraded the results on a novel object recognition task as compared with 5 hr. The present findings suggest that naturalistic NBM burst DBS may offer potential effective therapy for treating dementia and suggests potential strategies for the reevaluation of current human NBM stimulation paradigms. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.