Evidence map›Paper›PMID 40489030›Full record

ArticleBreast cancer (Tokyo, Japan)2025

Impact of margin status on ipsilateral breast tumor recurrence after breast-conserving treatment for patients with breast cancer who received neoadjuvant chemotherapy: a retrospective multi-institutional study of 1813 cases.

Makoto Ishitobi, Atsushi Yoshida, Yuri Kimura, Yasuaki Sagara, Yuka Ono, Koji Takada, Yuko Takahashi, Takahiro Tsukioki, Mao Kimoto, Tomo Osako and 2 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Breast cancer (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Makoto IshitobiDepartment of Breast Surgery, Osaka Habikino Medical Center, 3-7-1 Habikino, Habikino, Osaka, 583-0872, Japan. pu-tobi-100306@docomo.ne.jp.
Atsushi YoshidaDepartment of Breast Surgical Oncology, St. Luke's International Hospital, Tokyo, Japan.
Yuri KimuraDepartment of Breast Surgical Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.
Yasuaki SagaraDepartment of Breast and Thyroid Surgical Oncology, Social Medical Corporation Hakuaikai Sagara Hospital, Kagoshima, Japan.
Yuka OnoDepartment of Radiation Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Koji TakadaDepartment of Breast Surgical Oncology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Yuko TakahashiDepartment of Breast and Endocrine Surgery, Okayama University Hospital, Okayama, Japan.
Takahiro TsukiokiDepartment of Breast and Endocrine Surgery, Okayama University Hospital, Okayama, Japan.
Mao KimotoDepartment of Breast Surgery, Mie University School of Medicine, Tsu, Japan.
Tomo OsakoDivision of Pathology, The Cancer Institute of Japanese Foundation for Cancer Research, Tokyo, Japan.
Takehiko SakaiDepartment of Breast Surgical Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.
Collaborative Study Group of Scientific Research of the Japanese Breast Cancer Society

Funding

Japanese Breast Cancer Society 2023
6 · The paper itself

Abstract

backgroundThere is no consensus regarding the optimal margin status among patients with breast cancer treated with neoadjuvant chemotherapy (NAC), breast-conserving surgery, and radiotherapy (breast-conserving treatment [BCT]).

methodsIn total, 1813 patients with newly diagnosed stage 1-3 breast cancer who underwent BCT after NAC were evaluated to determine the impact of margin status on ipsilateral breast tumor recurrence (IBTR).

resultsDuring a median follow-up period of 8.0 years (range 0.1-17.0 years), the 8-year IBTR-free survival rate was 95.9%. Patients with positive margins had significantly worse IBTR-free survival than those with negative margins (8-year IBTR-free survival rate: 87.6% vs. 96.2%, p = 0.010). Multivariate analysis showed that margin status was significantly associated with IBTR-free survival (hazard ratio: 3.1; 95% confidence interval 1.3-7.2; p = 0.0081).

conclusionsThis multicenter retrospective study demonstrated that margin status is significantly associated with IBTR-free survival in patients who received NAC and BCT, consistent with findings in upfront-surgery cases.

Indexed as

Breast NeoplasmsMargins of ExcisionMastectomy, SegmentalNeoplasm Recurrence, LocalAdultAgedAged, 80 and overChemotherapy, AdjuvantDisease-Free SurvivalFemaleFollow-Up StudiesHumansMiddle AgedNeoadjuvant TherapyRetrospective StudiesYoung AdultBreast cancerBreast-conserving surgeryIpsilateral breast tumor recurrenceMargin statusNeoadjuvant chemotherapy

Identifiers

PMID40489030

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