ArticleHepatology international2025
Single-cell transcriptomic profiling reveals dysregulation of B-cell subset function in patients with chronic hepatitis B.
Article in Hepatology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Dysregulated BCR repertoire and metabolic state of HBsAg-specific B cells in chronic hepatitis B revealed by integrated single-cell analysis.Hepatology communications · 2026Article
- A preS2 aa1-26-specific humoural response marks functional cure in chronic HBV infection.EBioMedicine · 2026Article
- B-cell subset heterogeneity in the liver during chronic hepatitis B.Hepatology international · 2026Article
- Peripheral and intrahepatic B-cell subsets contribute to HBeAg seroconversion in patients with chronic hepatitis B.Virology journal · 2025Article
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Abstract
BACKGROUND AND
aimThe goal of this study was to investigate the immunological characteristics and potential clinical significance of B-cell subsets during different phases of hepatitis B virus (HBV) infection.
methodsWe conducted single-cell RNA sequencing on 23,967 B cells (including 1,677 plasma cells) derived from 46 liver and blood samples from 25 individuals. The study included six HBV-free healthy control (HC) cases, as well as subjects from four different HBV phases: six immune-tolerant (IT), six immune activation (IA), four acute recovery (AR), and three chronic resolved (CR) individuals. In addition, a separate cohort consisting of 10 IT, 13 IA, and 15 HC individuals was recruited for experimental validation.
resultsThe liver tissue of patients with chronic hepatitis B (CHB) exhibited enriched atypical B-cell (ABC) and FCRL1
conclusionOur study provides a comprehensive analysis of the composition and functional characteristics of B-cell subsets in HBV-infected individuals at various clinical phases. It also identifies the potential mechanism responsible for humoral immunity in cases of HBV infection.
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