ReviewJournal of physiology and biochemistry2025
Crosstalk between MST1-Hippo and Wnt/β-Catenin, Notch, and PI3K/Akt pathways in cardiac physiology and pathology.
Review in Journal of physiology and biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Secreted frizzled-related protein 2 as a context-dependent extracellular signaling hub in development, tissue remodeling, and disease.Frontiers in cell and developmental biology · 2026Review
- AI-Guided Discovery of Oncogenic Signaling Crosstalk in Tumor Progression and Drug Resistance.Oncology research · 2026Review
- The epidermal growth factor receptor regulates YAP signalling and promotes diabetic retinal fibrosis by modulating the degradation of SAV1.Journal of translational medicine · 2025Article
- Notch signaling pathway and heart development, congenital heart disease, and myocardial regeneration.Frontiers in bioengineering and biotechnology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies in cardiac biology have identified a complex interplay between the Hippo, Wnt/β-catenin, and Notch signaling pathways, establishing an integrated regulatory network that influences cardiac growth and function. Deletion of MST1/2 activates the YAP/TAZ, STAT3, Wnt/β-catenin, and Notch pathways, highlighting the key role of YAP/TAZ in facilitating the crosstalk of these pathways. Activation of the Wnt/β-catenin pathway inhibits the positive feedback loop between Notch signaling and YAP/TAZ, elucidating the dynamic balance of these signaling systems. Communication between YAP and β-catenin in the nucleus regulates the expression of genes associated with cell proliferation and reprogramming, including Sox2 and Snai2. Although YAP forms a complex with the transcription factors TEAD/TEF while β-catenin with LEF/TCF, the two pathways exhibit distinct regulatory functions with partial overlap in gene targets. The Hippo pathway regulates heart size and cardiomyocyte proliferation by inhibiting Wnt/β-catenin signaling. Disruption of this balance can result in aberrant cardiac development and associated diseases, highlighting the need for a thorough understanding of these interactions. Therapeutics targeting of these signaling pathways have the potential to impact cardiac development and repair, creating new treatment options for heart disease.
Indexed as
Identifiers
40489018What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.