ArticleSmall (Weinheim an der Bergstrasse, Germany)2025
Cytotransducers for Visualization of Spatiotemporal Intercellular Communication.
Article in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Materiobiology-guided regulation of mesenchymal stromal cell fate for aging-related diseases: From basic parameter design to clinical application.Bioactive materials · 2026Review
- Cytotransducers for Visualization of Spatiotemporal Intercellular Communication.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Visualization of intercellular communication provides a means for understanding and leveraging complicated multicellular organizations. Various nanometer-sized artifacts (nano-artifacts) can be employed as small tracers for visualization, achieving spatially and temporally controlled intervention of these small tracers in the interactions remains challenging due to their diffusion-based transportation. To achieve spatiotemporally controlled visualization, cytotransducers are conceptualized that convert veiled intra/intercellular information into visible information. A 110-mm cytotransducer is presented, composed of a lipid layer and a fluorescent nanodiamond. The designed lipid layer allows effective uptake of the cytotransducer by neutrophils, and the fluorescent nanodiamond is labeled with the pH-responsive chemical fluorescein isothiocyanate to visualize the intracellular local pH at the single-cell level. Utilizing cytotransducers, cross-scale visualization of intercellular communication between neutrophils and three types of cells: macrophages, aged cells, and mesenchymal stem cells is demonstrated. Intracellular pH maps are obtained before and during the interactions, achieving spatiotemporally controlled visualization of intercellular communication based on the localized release of cytotransducers by programmed cell death (NETosis). A well-designed cytotransducer allows the simultaneous visualization of intra/intercellular information under spatiotemporally controlled conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.